Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene

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Standard

Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. / Nimsanor, Natakarn; Kitiyanant, Narisorn; Poulsen, Ulla; Rasmussen, Mikkel A.; Clausen, Christian; Mau-Holzmann, Ulrike A; Nielsen, Jørgen E; Nielsen, Troels T; Hyttel, Poul; Holst, Bjørn; Schmid, Benjamin.

In: Stem Cell Research, Vol. 17, No. 3, 11.2016, p. 556-559.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nimsanor, N, Kitiyanant, N, Poulsen, U, Rasmussen, MA, Clausen, C, Mau-Holzmann, UA, Nielsen, JE, Nielsen, TT, Hyttel, P, Holst, B & Schmid, B 2016, 'Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene', Stem Cell Research, vol. 17, no. 3, pp. 556-559. https://doi.org/10.1016/j.scr.2016.09.021

APA

Nimsanor, N., Kitiyanant, N., Poulsen, U., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Nielsen, J. E., Nielsen, T. T., Hyttel, P., Holst, B., & Schmid, B. (2016). Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research, 17(3), 556-559. https://doi.org/10.1016/j.scr.2016.09.021

Vancouver

Nimsanor N, Kitiyanant N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA et al. Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research. 2016 Nov;17(3):556-559. https://doi.org/10.1016/j.scr.2016.09.021

Author

Nimsanor, Natakarn ; Kitiyanant, Narisorn ; Poulsen, Ulla ; Rasmussen, Mikkel A. ; Clausen, Christian ; Mau-Holzmann, Ulrike A ; Nielsen, Jørgen E ; Nielsen, Troels T ; Hyttel, Poul ; Holst, Bjørn ; Schmid, Benjamin. / Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. In: Stem Cell Research. 2016 ; Vol. 17, No. 3. pp. 556-559.

Bibtex

@article{30089e92a6f3447a9df7c717e338b411,
title = "Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene",
abstract = "Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau)-gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required cell type. Furthermore, gene-editing approaches allow generating isogenic gene-corrected controls that can be used as a very specific control. Here, we report the generation of genetically corrected iPSCs from a 57-year-old female FTD-17 patient carrying an P301L mutation in the MAPT-gene.",
author = "Natakarn Nimsanor and Narisorn Kitiyanant and Ulla Poulsen and Rasmussen, {Mikkel A.} and Christian Clausen and Mau-Holzmann, {Ulrike A} and Nielsen, {J{\o}rgen E} and Nielsen, {Troels T} and Poul Hyttel and Bj{\o}rn Holst and Benjamin Schmid",
note = "Copyright {\textcopyright} 2016. Published by Elsevier B.V.",
year = "2016",
month = nov,
doi = "10.1016/j.scr.2016.09.021",
language = "English",
volume = "17",
pages = "556--559",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene

AU - Nimsanor, Natakarn

AU - Kitiyanant, Narisorn

AU - Poulsen, Ulla

AU - Rasmussen, Mikkel A.

AU - Clausen, Christian

AU - Mau-Holzmann, Ulrike A

AU - Nielsen, Jørgen E

AU - Nielsen, Troels T

AU - Hyttel, Poul

AU - Holst, Bjørn

AU - Schmid, Benjamin

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2016/11

Y1 - 2016/11

N2 - Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau)-gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required cell type. Furthermore, gene-editing approaches allow generating isogenic gene-corrected controls that can be used as a very specific control. Here, we report the generation of genetically corrected iPSCs from a 57-year-old female FTD-17 patient carrying an P301L mutation in the MAPT-gene.

AB - Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau)-gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required cell type. Furthermore, gene-editing approaches allow generating isogenic gene-corrected controls that can be used as a very specific control. Here, we report the generation of genetically corrected iPSCs from a 57-year-old female FTD-17 patient carrying an P301L mutation in the MAPT-gene.

U2 - 10.1016/j.scr.2016.09.021

DO - 10.1016/j.scr.2016.09.021

M3 - Journal article

C2 - 27789409

VL - 17

SP - 556

EP - 559

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

IS - 3

ER -

ID: 172816727