Novel insights into cerebral palsy
Research output: Contribution to journal › Comment/debate › Research › peer-review
Standard
Novel insights into cerebral palsy. / Bartels, Else Marie; Korbo, Lise; Harrison, Adrian P.
In: Journal of Muscle Research and Cell Motility, Vol. 41, No. 2-3, 2020, p. 265-267.Research output: Contribution to journal › Comment/debate › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Novel insights into cerebral palsy
AU - Bartels, Else Marie
AU - Korbo, Lise
AU - Harrison, Adrian P.
PY - 2020
Y1 - 2020
N2 - Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. CP affects about 1 in 500 neonates. CP shows clinical features which evolve with age, and these may over time lead to deterioration of motor function although the lesion to the developing brain is non-progressive. The underlying causes for CP remain unclear. Based on recent research we are able to give a physiological explanation on the appearance and development of the condition. The damage to the central nervous system causes a change in collagen structure, with a higher level of deposition of collagen around the muscles, increasing throughout life. Assuming this premise is correct, the question is, will it by any treatment be possible to delay or prevent this collagen accumulation in the CP muscles, thereby giving CP patients a better prognosis in the future.
AB - Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. CP affects about 1 in 500 neonates. CP shows clinical features which evolve with age, and these may over time lead to deterioration of motor function although the lesion to the developing brain is non-progressive. The underlying causes for CP remain unclear. Based on recent research we are able to give a physiological explanation on the appearance and development of the condition. The damage to the central nervous system causes a change in collagen structure, with a higher level of deposition of collagen around the muscles, increasing throughout life. Assuming this premise is correct, the question is, will it by any treatment be possible to delay or prevent this collagen accumulation in the CP muscles, thereby giving CP patients a better prognosis in the future.
KW - Cerebral palsy
KW - Collagen
KW - Muscle
U2 - 10.1007/s10974-020-09577-4
DO - 10.1007/s10974-020-09577-4
M3 - Comment/debate
C2 - 32065339
AN - SCOPUS:85082946681
VL - 41
SP - 265
EP - 267
JO - Journal of Muscle Research and Cell Motility
JF - Journal of Muscle Research and Cell Motility
SN - 0142-4319
IS - 2-3
ER -
ID: 282475179