Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes

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Standard

Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes. / Chettri, Jiwan Kumar; Mehrdana, Foojan; Hansen, E.B; Ebbensgaard, A; Overgaard, M.T; Lauritsen, A.H; Dalsgaard, I; Buchmann, Kurt.

I: Journal of Fish Diseases, Bind 40, Nr. 1, 01.2017, s. 97-104.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Chettri, JK, Mehrdana, F, Hansen, EB, Ebbensgaard, A, Overgaard, MT, Lauritsen, AH, Dalsgaard, I & Buchmann, K 2017, 'Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes', Journal of Fish Diseases, bind 40, nr. 1, s. 97-104. https://doi.org/10.1111/jfd.12497

APA

Chettri, J. K., Mehrdana, F., Hansen, E. B., Ebbensgaard, A., Overgaard, M. T., Lauritsen, A. H., Dalsgaard, I., & Buchmann, K. (2017). Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes. Journal of Fish Diseases, 40(1), 97-104. https://doi.org/10.1111/jfd.12497

Vancouver

Chettri JK, Mehrdana F, Hansen EB, Ebbensgaard A, Overgaard MT, Lauritsen AH o.a. Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes. Journal of Fish Diseases. 2017 jan.;40(1):97-104. https://doi.org/10.1111/jfd.12497

Author

Chettri, Jiwan Kumar ; Mehrdana, Foojan ; Hansen, E.B ; Ebbensgaard, A ; Overgaard, M.T ; Lauritsen, A.H ; Dalsgaard, I ; Buchmann, Kurt. / Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes. I: Journal of Fish Diseases. 2017 ; Bind 40, Nr. 1. s. 97-104.

Bibtex

@article{c2a901fdbccf41e7ab0b5564e293d599,
title = "Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes",
abstract = "The antimicrobial peptide CAP18 has been demonstrated to have a strong in vitro bactericidal effect on Yersinia ruckeri, but its activity in vivo has not been described. In this work, we investigated whether CAP18 protects rainbow trout Oncorhynchus mykiss (Walbaum) against enteric red mouth disease caused by this pathogen either following i.p. injection or by oral administration (in feed). It was found that injection of CAP18 into juvenile rainbow trout before exposure to Y. ruckeri was associated with lowered mortality compared to non-medicated fish although it was less effective than the conventional antibiotic oxolinic acid. Oral administration of CAP18 to trout did not prevent infection. The proteolytic effect of secretions on the peptide CAP18 in the fish gastrointestinal tract is suggested to account for the inferior effect of oral administration.",
author = "Chettri, {Jiwan Kumar} and Foojan Mehrdana and E.B Hansen and A Ebbensgaard and M.T Overgaard and A.H Lauritsen and I Dalsgaard and Kurt Buchmann",
year = "2017",
month = jan,
doi = "10.1111/jfd.12497",
language = "English",
volume = "40",
pages = "97--104",
journal = "Journal of Fish Diseases",
issn = "0140-7775",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Antimicrobial peptide CAP18 and its effect on Yersinia ruckeri infections in rainbow trout Oncorhynchus mykiss (Walbaum): comparing administration by injection and oral routes

AU - Chettri, Jiwan Kumar

AU - Mehrdana, Foojan

AU - Hansen, E.B

AU - Ebbensgaard, A

AU - Overgaard, M.T

AU - Lauritsen, A.H

AU - Dalsgaard, I

AU - Buchmann, Kurt

PY - 2017/1

Y1 - 2017/1

N2 - The antimicrobial peptide CAP18 has been demonstrated to have a strong in vitro bactericidal effect on Yersinia ruckeri, but its activity in vivo has not been described. In this work, we investigated whether CAP18 protects rainbow trout Oncorhynchus mykiss (Walbaum) against enteric red mouth disease caused by this pathogen either following i.p. injection or by oral administration (in feed). It was found that injection of CAP18 into juvenile rainbow trout before exposure to Y. ruckeri was associated with lowered mortality compared to non-medicated fish although it was less effective than the conventional antibiotic oxolinic acid. Oral administration of CAP18 to trout did not prevent infection. The proteolytic effect of secretions on the peptide CAP18 in the fish gastrointestinal tract is suggested to account for the inferior effect of oral administration.

AB - The antimicrobial peptide CAP18 has been demonstrated to have a strong in vitro bactericidal effect on Yersinia ruckeri, but its activity in vivo has not been described. In this work, we investigated whether CAP18 protects rainbow trout Oncorhynchus mykiss (Walbaum) against enteric red mouth disease caused by this pathogen either following i.p. injection or by oral administration (in feed). It was found that injection of CAP18 into juvenile rainbow trout before exposure to Y. ruckeri was associated with lowered mortality compared to non-medicated fish although it was less effective than the conventional antibiotic oxolinic acid. Oral administration of CAP18 to trout did not prevent infection. The proteolytic effect of secretions on the peptide CAP18 in the fish gastrointestinal tract is suggested to account for the inferior effect of oral administration.

U2 - 10.1111/jfd.12497

DO - 10.1111/jfd.12497

M3 - Journal article

C2 - 27334068

VL - 40

SP - 97

EP - 104

JO - Journal of Fish Diseases

JF - Journal of Fish Diseases

SN - 0140-7775

IS - 1

ER -

ID: 164752274