Emission of selected volatile organic compounds (VOCs), such as methylamine (MA), dimethylamine (DMA), and trimethylamine (TMA), is associated with certain microbial reactions, causing intrinsic decomposition and spoilage of meat and fish. Efficient detection of MA, DMA, and TMA is vital for meat and fish spoilage assessment. Here, density functional theory (DFT) calculations are used to study the sensing properties of selected MXene monolayers (M₂CT_x; M = Ti, Nb, V; T_x = O, OH, F) toward MA, DMA, and TMA. We found that the binding energies of MA (−0.29 to −1.08 eV), DMA (−0.39 to −1.15 eV), and TMA (−0.28 to −1.19 eV) on M₂CT_x are ideal for reversible sensing. Appropriate binding of these VOCs is associated with measurable changes in the electronic properties of M₂CT_x, which is essential for a highly efficient sensing mechanism. Further, we used the Langmuir adsorption model to explore the sensing characteristics of M₂CT_x monolayers in varied temperature and pressure environments. Among the studied systems, Nb₂C(OH)₂ exhibits excellent sensing capabilities toward DMA and TMA at concentrations below parts per million (ppm), whereas Nb₂CF₂ exhibits selective adsorption of MA at concentrations below ppm. We strongly believe that our findings will pave the way for the development of highly sensitive nanosensors for monitoring the spoilage of meat and fish products.