Diet-microbiota crosstalk and immunity to helminth infection
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Diet-microbiota crosstalk and immunity to helminth infection. / Myhill, Laura J.; Williams, Andrew R.
I: Parasite Immunology, Bind 45, Nr. 4, 12965, 2023.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Diet-microbiota crosstalk and immunity to helminth infection
AU - Myhill, Laura J.
AU - Williams, Andrew R.
N1 - Publisher Copyright: © 2022 The Authors. Parasite Immunology published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Helminths are large multicellular parasites responsible for widespread chronic disease in humans and animals. Intestinal helminths live in close proximity with the host gut microbiota and mucosal immune network, resulting in reciprocal interactions that closely influence the course of infections. Diet composition may strongly regulate gut microbiota composition and intestinal immune function and therefore may play a key role in modulating anti-helminth immune responses. Characterizing the multitude of interactions that exist between different dietary components (e.g., dietary fibres), immune cells, and the microbiota, may shed new light on regulation of helminth-specific immunity. This review focuses on the current knowledge of how metabolism of dietary components shapes immune response during helminth infection, and how this information may be potentially harnessed to design new therapeutics to manage parasitic infections and associated diseases.
AB - Helminths are large multicellular parasites responsible for widespread chronic disease in humans and animals. Intestinal helminths live in close proximity with the host gut microbiota and mucosal immune network, resulting in reciprocal interactions that closely influence the course of infections. Diet composition may strongly regulate gut microbiota composition and intestinal immune function and therefore may play a key role in modulating anti-helminth immune responses. Characterizing the multitude of interactions that exist between different dietary components (e.g., dietary fibres), immune cells, and the microbiota, may shed new light on regulation of helminth-specific immunity. This review focuses on the current knowledge of how metabolism of dietary components shapes immune response during helminth infection, and how this information may be potentially harnessed to design new therapeutics to manage parasitic infections and associated diseases.
KW - immune modulation
KW - immunological terms
KW - mucosal immunity
U2 - 10.1111/pim.12965
DO - 10.1111/pim.12965
M3 - Review
C2 - 36571323
AN - SCOPUS:85146295955
VL - 45
JO - Parasite Immunology
JF - Parasite Immunology
SN - 0141-9838
IS - 4
M1 - 12965
ER -
ID: 334261163