Excretory/secretory products of anisakid nematodes: Biological and pathological roles
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Excretory/secretory products of anisakid nematodes : Biological and pathological roles. / Mehrdana, Foojan; Buchmann, Kurt.
I: Acta Veterinaria Scandinavica, Bind 59, Nr. 1, 42, 2017.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Excretory/secretory products of anisakid nematodes
T2 - Biological and pathological roles
AU - Mehrdana, Foojan
AU - Buchmann, Kurt
PY - 2017
Y1 - 2017
N2 - Parasites from the family Anisakidae are widely distributed in marine fish populations worldwide and mainly nematodes of the three genera Anisakis, Pseudoterranova and Contracaecum have attracted attention due to their pathogenicity in humans. Their life cycles include invertebrates and fish as intermediate or transport hosts and mammals or birds as final hosts. Human consumption of raw or underprocessed seafood containing third stage larvae of anisakid parasites may elicit a gastrointestinal disease (anisakidosis) and allergic responses. Excretory and secretory (ES) compounds produced by the parasites are assumed to be key players in clinical manifestation of the disease in humans, but the molecules are likely to play a general biological role in invertebrates and lower vertebrates as well. ES products have several functions during infection, e.g. penetration of host tissues and evasion of host immune responses, but are at the same time known to elicit immune responses (including antibody production) both in fish and mammals. ES proteins from anisakid nematodes, in particular Anisakis simplex, are currently applied for diagnostic purposes but recent evidence suggests that they also may have a therapeutic potential in immune-related diseases.
AB - Parasites from the family Anisakidae are widely distributed in marine fish populations worldwide and mainly nematodes of the three genera Anisakis, Pseudoterranova and Contracaecum have attracted attention due to their pathogenicity in humans. Their life cycles include invertebrates and fish as intermediate or transport hosts and mammals or birds as final hosts. Human consumption of raw or underprocessed seafood containing third stage larvae of anisakid parasites may elicit a gastrointestinal disease (anisakidosis) and allergic responses. Excretory and secretory (ES) compounds produced by the parasites are assumed to be key players in clinical manifestation of the disease in humans, but the molecules are likely to play a general biological role in invertebrates and lower vertebrates as well. ES products have several functions during infection, e.g. penetration of host tissues and evasion of host immune responses, but are at the same time known to elicit immune responses (including antibody production) both in fish and mammals. ES proteins from anisakid nematodes, in particular Anisakis simplex, are currently applied for diagnostic purposes but recent evidence suggests that they also may have a therapeutic potential in immune-related diseases.
KW - Allergy
KW - Anisakidosis
KW - Anisakids
KW - Excretory/secretory products
U2 - 10.1186/s13028-017-0310-3
DO - 10.1186/s13028-017-0310-3
M3 - Review
C2 - 28645306
AN - SCOPUS:85021223910
VL - 59
JO - Acta Veterinaria Scandinavica
JF - Acta Veterinaria Scandinavica
SN - 0044-605X
IS - 1
M1 - 42
ER -
ID: 184391140