Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons. / Hansen, Tina Vicky Alstrup; Thamsborg, Stig Milan; Olsen, Annette; Prichard, Roger K.; Nejsum, Peter.

I: Parasites & Vectors, Bind 6, 236, 2013.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, TVA, Thamsborg, SM, Olsen, A, Prichard, RK & Nejsum, P 2013, 'Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons', Parasites & Vectors, bind 6, 236. https://doi.org/10.1186/1756-3305-6-236

APA

Hansen, T. V. A., Thamsborg, S. M., Olsen, A., Prichard, R. K., & Nejsum, P. (2013). Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons. Parasites & Vectors, 6, [236]. https://doi.org/10.1186/1756-3305-6-236

Vancouver

Hansen TVA, Thamsborg SM, Olsen A, Prichard RK, Nejsum P. Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons. Parasites & Vectors. 2013;6. 236. https://doi.org/10.1186/1756-3305-6-236

Author

Hansen, Tina Vicky Alstrup ; Thamsborg, Stig Milan ; Olsen, Annette ; Prichard, Roger K. ; Nejsum, Peter. / Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons. I: Parasites & Vectors. 2013 ; Bind 6.

Bibtex

@article{90a8ebf8e2534a7dabd0da9d69e12907,
title = "Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons",
abstract = "The whipworm Trichuris trichiura has been estimated to infect 604 -- 795 million people worldwide. The current control strategy against trichuriasis using the benzimidazoles (BZs) albendazole (400 mg) or mebendazole (500 mg) as single-dose treatment is not satisfactory. The occurrence of single nucleotide polymorphisms (SNPs) in codons 167, 198 or 200 of the beta-tubulin gene has been reported to convey BZ-resistance in intestinal nematodes of veterinary importance. It was hypothesised that the low susceptibility of T. trichiura to BZ could be due to a natural occurrence of such SNPs. The aim of this study was to investigate whether these SNPs were present in the beta-tubulin gene of Trichuris spp. from humans and baboons. As a secondary objective, the degree of identity between T. trichiura from humans and Trichuris spp. from baboons was evaluated based on the beta-tubulin gene and the internal transcribed spacer 2 region (ITS2).",
author = "Hansen, {Tina Vicky Alstrup} and Thamsborg, {Stig Milan} and Annette Olsen and Prichard, {Roger K.} and Peter Nejsum",
year = "2013",
doi = "10.1186/1756-3305-6-236",
language = "English",
volume = "6",
journal = "Parasites & Vectors",
issn = "1756-3305",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Genetic variations in the beta-tubulin gene and the internal transcribed spacer 2 region of Trichuris species from man and baboons

AU - Hansen, Tina Vicky Alstrup

AU - Thamsborg, Stig Milan

AU - Olsen, Annette

AU - Prichard, Roger K.

AU - Nejsum, Peter

PY - 2013

Y1 - 2013

N2 - The whipworm Trichuris trichiura has been estimated to infect 604 -- 795 million people worldwide. The current control strategy against trichuriasis using the benzimidazoles (BZs) albendazole (400 mg) or mebendazole (500 mg) as single-dose treatment is not satisfactory. The occurrence of single nucleotide polymorphisms (SNPs) in codons 167, 198 or 200 of the beta-tubulin gene has been reported to convey BZ-resistance in intestinal nematodes of veterinary importance. It was hypothesised that the low susceptibility of T. trichiura to BZ could be due to a natural occurrence of such SNPs. The aim of this study was to investigate whether these SNPs were present in the beta-tubulin gene of Trichuris spp. from humans and baboons. As a secondary objective, the degree of identity between T. trichiura from humans and Trichuris spp. from baboons was evaluated based on the beta-tubulin gene and the internal transcribed spacer 2 region (ITS2).

AB - The whipworm Trichuris trichiura has been estimated to infect 604 -- 795 million people worldwide. The current control strategy against trichuriasis using the benzimidazoles (BZs) albendazole (400 mg) or mebendazole (500 mg) as single-dose treatment is not satisfactory. The occurrence of single nucleotide polymorphisms (SNPs) in codons 167, 198 or 200 of the beta-tubulin gene has been reported to convey BZ-resistance in intestinal nematodes of veterinary importance. It was hypothesised that the low susceptibility of T. trichiura to BZ could be due to a natural occurrence of such SNPs. The aim of this study was to investigate whether these SNPs were present in the beta-tubulin gene of Trichuris spp. from humans and baboons. As a secondary objective, the degree of identity between T. trichiura from humans and Trichuris spp. from baboons was evaluated based on the beta-tubulin gene and the internal transcribed spacer 2 region (ITS2).

U2 - 10.1186/1756-3305-6-236

DO - 10.1186/1756-3305-6-236

M3 - Journal article

C2 - 23938038

VL - 6

JO - Parasites & Vectors

JF - Parasites & Vectors

SN - 1756-3305

M1 - 236

ER -

ID: 61667286