Mitochondrial and nuclear ribosomal DNA evidence supports the existence of a new Trichuris species in the endangered François' leaf-monkey
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Mitochondrial and nuclear ribosomal DNA evidence supports the existence of a new Trichuris species in the endangered François' leaf-monkey. / Liu, Guo-Hua; Gasser, Robin B.; Nejsum, Peter; Wang, Yan; Chen, Qiang; Song, Hui-Qun; Zhu, Xing-Quan.
I: PLOS ONE, Bind 8, Nr. 6, e66249, 2013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Mitochondrial and nuclear ribosomal DNA evidence supports the existence of a new Trichuris species in the endangered François' leaf-monkey
AU - Liu, Guo-Hua
AU - Gasser, Robin B.
AU - Nejsum, Peter
AU - Wang, Yan
AU - Chen, Qiang
AU - Song, Hui-Qun
AU - Zhu, Xing-Quan
PY - 2013
Y1 - 2013
N2 - The whipworm of humans, Trichuris trichiura, is responsible for a neglected tropical disease (NTD) of major importance in tropical and subtropical countries of the world. Whipworms also infect animal hosts, including pigs, dogs and non-human primates, cause clinical disease (trichuriasis) similar to that of humans. Although Trichuris species are usually considered to be host specific, it is not clear whether non-human primates are infected with T. trichiura or other species. In the present study, we sequenced the complete mitochondrial (mt) genome as well as the first and second internal transcribed spacers (ITS-1 and ITS-2) of Trichuris from the François' leaf-monkey (langur), and compared them with homologous sequences from human- and pig-derived Trichuris. In addition, sequence comparison of a conserved mt ribosomal gene among multiple individual whipworms revealed substantial nucleotide differences among these three host species but limited sequence variation within each of them. The molecular data indicate that the monkey-derived whipworm is a separate species from that of humans. Future work should focus on detailed population genetic and morphological studies (by electron microscopy) of whipworms from various non-humans primates and humans.
AB - The whipworm of humans, Trichuris trichiura, is responsible for a neglected tropical disease (NTD) of major importance in tropical and subtropical countries of the world. Whipworms also infect animal hosts, including pigs, dogs and non-human primates, cause clinical disease (trichuriasis) similar to that of humans. Although Trichuris species are usually considered to be host specific, it is not clear whether non-human primates are infected with T. trichiura or other species. In the present study, we sequenced the complete mitochondrial (mt) genome as well as the first and second internal transcribed spacers (ITS-1 and ITS-2) of Trichuris from the François' leaf-monkey (langur), and compared them with homologous sequences from human- and pig-derived Trichuris. In addition, sequence comparison of a conserved mt ribosomal gene among multiple individual whipworms revealed substantial nucleotide differences among these three host species but limited sequence variation within each of them. The molecular data indicate that the monkey-derived whipworm is a separate species from that of humans. Future work should focus on detailed population genetic and morphological studies (by electron microscopy) of whipworms from various non-humans primates and humans.
U2 - 10.1371/journal.pone.0066249
DO - 10.1371/journal.pone.0066249
M3 - Journal article
C2 - 23840431
VL - 8
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 6
M1 - e66249
ER -
ID: 66701772