Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
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Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. / Xu, Zhen; Takizawa, Fumio; Parra, David; Gomez, Daniela; Jørgensen, Louise von Gersdorff; LaPatra, Scott E.; Sunyer, J. Oriol.
I: Nature Communications, Bind 7, 10728, 2016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
AU - Xu, Zhen
AU - Takizawa, Fumio
AU - Parra, David
AU - Gomez, Daniela
AU - Jørgensen, Louise von Gersdorff
AU - LaPatra, Scott E.
AU - Sunyer, J. Oriol
PY - 2016
Y1 - 2016
N2 - Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT+ B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods.
AB - Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT+ B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods.
U2 - 10.1038/ncomms10728
DO - 10.1038/ncomms10728
M3 - Journal article
C2 - 26869478
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 10728
ER -
ID: 156037846