Emergence of methicillin resistance predates the clinical use of antibiotics
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Emergence of methicillin resistance predates the clinical use of antibiotics. / Larsen, Jesper; Raisen, Claire L.; Ba, Xiaoliang; Sadgrove, Nicholas J.; Padilla-González, Guillermo F.; Simmonds, Monique S.J.; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Arendrup, Maiken C.; Hare, Rasmus K.; Barnadas, Céline; Stegger, Marc; Sieber, Raphael N.; Skov, Robert L.; Petersen, Andreas; Angen, Øystein; Rasmussen, Sophie L.; Espinosa-Gongora, Carmen; Aarestrup, Frank M.; Lindholm, Laura J.; Nykäsenoja, Suvi M.; Laurent, Frederic; Becker, Karsten; Walther, Birgit; Kehrenberg, Corinna; Cuny, Christiane; Layer, Franziska; Werner, Guido; Witte, Wolfgang; Stamm, Ivonne; Moroni, Paolo; Jørgensen, Hannah J.; de Lencastre, Hermínia; Cercenado, Emilia; García-Garrote, Fernando; Börjesson, Stefan; Hæggman, Sara; Perreten, Vincent; Teale, Christopher J.; Waller, Andrew S.; Pichon, Bruno; Curran, Martin D.; Ellington, Matthew J.; Welch, John J.; Peacock, Sharon J.; Seilly, David J.; Morgan, Fiona J.E.; Parkhill, Julian; Hadjirin, Nazreen F.; Lindsay, Jodi A.; Holden, Matthew T.G.; Edwards, Giles F.; Foster, Geoffrey; Paterson, Gavin K.; Didelot, Xavier; Holmes, Mark A.; Harrison, Ewan M.; Larsen, Anders R.
I: Nature, Bind 602, 2022, s. 135–141.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Emergence of methicillin resistance predates the clinical use of antibiotics
AU - Larsen, Jesper
AU - Raisen, Claire L.
AU - Ba, Xiaoliang
AU - Sadgrove, Nicholas J.
AU - Padilla-González, Guillermo F.
AU - Simmonds, Monique S.J.
AU - Loncaric, Igor
AU - Kerschner, Heidrun
AU - Apfalter, Petra
AU - Hartl, Rainer
AU - Deplano, Ariane
AU - Vandendriessche, Stien
AU - Černá Bolfíková, Barbora
AU - Hulva, Pavel
AU - Arendrup, Maiken C.
AU - Hare, Rasmus K.
AU - Barnadas, Céline
AU - Stegger, Marc
AU - Sieber, Raphael N.
AU - Skov, Robert L.
AU - Petersen, Andreas
AU - Angen, Øystein
AU - Rasmussen, Sophie L.
AU - Espinosa-Gongora, Carmen
AU - Aarestrup, Frank M.
AU - Lindholm, Laura J.
AU - Nykäsenoja, Suvi M.
AU - Laurent, Frederic
AU - Becker, Karsten
AU - Walther, Birgit
AU - Kehrenberg, Corinna
AU - Cuny, Christiane
AU - Layer, Franziska
AU - Werner, Guido
AU - Witte, Wolfgang
AU - Stamm, Ivonne
AU - Moroni, Paolo
AU - Jørgensen, Hannah J.
AU - de Lencastre, Hermínia
AU - Cercenado, Emilia
AU - García-Garrote, Fernando
AU - Börjesson, Stefan
AU - Hæggman, Sara
AU - Perreten, Vincent
AU - Teale, Christopher J.
AU - Waller, Andrew S.
AU - Pichon, Bruno
AU - Curran, Martin D.
AU - Ellington, Matthew J.
AU - Welch, John J.
AU - Peacock, Sharon J.
AU - Seilly, David J.
AU - Morgan, Fiona J.E.
AU - Parkhill, Julian
AU - Hadjirin, Nazreen F.
AU - Lindsay, Jodi A.
AU - Holden, Matthew T.G.
AU - Edwards, Giles F.
AU - Foster, Geoffrey
AU - Paterson, Gavin K.
AU - Didelot, Xavier
AU - Holmes, Mark A.
AU - Harrison, Ewan M.
AU - Larsen, Anders R.
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development.
AB - The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development.
U2 - 10.1038/s41586-021-04265-w
DO - 10.1038/s41586-021-04265-w
M3 - Journal article
C2 - 34987223
AN - SCOPUS:85122332898
VL - 602
SP - 135
EP - 141
JO - Nature
JF - Nature
SN - 0028-0836
ER -
ID: 290526005