Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens

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Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens. / Liang, Yuan; Hjulsager, Charlotte K.; Seekings, Amanda H.; Warren, Caroline J.; Lean, Fabian Z.X.; Núñez, Alejandro; James, Joe; Thomas, Saumya S.; Banyard, Ashley C.; Slomka, Marek J.; Brown, Ian H.; Larsen, Lars E.

I: Virology, Bind 577, 2022, s. 138-148.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Liang, Y, Hjulsager, CK, Seekings, AH, Warren, CJ, Lean, FZX, Núñez, A, James, J, Thomas, SS, Banyard, AC, Slomka, MJ, Brown, IH & Larsen, LE 2022, 'Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens', Virology, bind 577, s. 138-148. https://doi.org/10.1016/j.virol.2022.10.009

APA

Liang, Y., Hjulsager, C. K., Seekings, A. H., Warren, C. J., Lean, F. Z. X., Núñez, A., James, J., Thomas, S. S., Banyard, A. C., Slomka, M. J., Brown, I. H., & Larsen, L. E. (2022). Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens. Virology, 577, 138-148. https://doi.org/10.1016/j.virol.2022.10.009

Vancouver

Liang Y, Hjulsager CK, Seekings AH, Warren CJ, Lean FZX, Núñez A o.a. Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens. Virology. 2022;577:138-148. https://doi.org/10.1016/j.virol.2022.10.009

Author

Liang, Yuan ; Hjulsager, Charlotte K. ; Seekings, Amanda H. ; Warren, Caroline J. ; Lean, Fabian Z.X. ; Núñez, Alejandro ; James, Joe ; Thomas, Saumya S. ; Banyard, Ashley C. ; Slomka, Marek J. ; Brown, Ian H. ; Larsen, Lars E. / Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens. I: Virology. 2022 ; Bind 577. s. 138-148.

Bibtex

@article{b573ed3c342c4c83a17782a65f1194d1,
title = "Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens",
abstract = "High pathogenicity avian influenza viruses clade 2.3.4.4 H5 have spread among wild birds worldwide during recent years causing annual die-offs among wild birds and outbreaks in poultry in multiple European countries. The outbreaks significantly impact the poultry and game bird sectors. Infected game birds may act as a bridging species potentially enabling spread of virus into commercial and backyard premises. In this study, the pathogenesis and transmission of a HPAIV clade 2.3.4.4b H5N6 virus was investigated in pheasants and chickens. Efficient virus transmission was detected between pheasants over multiple rounds of na{\"i}ve pheasant introductions and onwards to chickens. Mortality of up to 100% was observed for both infected pheasants and chickens. Intra-species transmission from chicken to chicken was less efficient. The study confirmed that clade 2.3.4.4b H5N6 HPAIV is highly virulent in pheasants and emphasises the role of pheasants as a bridging host for the infection of commercial poultry.",
keywords = "Avian, Chicken, Epidemic, Game bird, HPAIV, Influenza, Pathogenesis, Pheasant, Transmission",
author = "Yuan Liang and Hjulsager, {Charlotte K.} and Seekings, {Amanda H.} and Warren, {Caroline J.} and Lean, {Fabian Z.X.} and Alejandro N{\'u}{\~n}ez and Joe James and Thomas, {Saumya S.} and Banyard, {Ashley C.} and Slomka, {Marek J.} and Brown, {Ian H.} and Larsen, {Lars E.}",
note = "Publisher Copyright: {\textcopyright} 2022",
year = "2022",
doi = "10.1016/j.virol.2022.10.009",
language = "English",
volume = "577",
pages = "138--148",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Pathogenesis and infection dynamics of high pathogenicity avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) in pheasants and onward transmission to chickens

AU - Liang, Yuan

AU - Hjulsager, Charlotte K.

AU - Seekings, Amanda H.

AU - Warren, Caroline J.

AU - Lean, Fabian Z.X.

AU - Núñez, Alejandro

AU - James, Joe

AU - Thomas, Saumya S.

AU - Banyard, Ashley C.

AU - Slomka, Marek J.

AU - Brown, Ian H.

AU - Larsen, Lars E.

N1 - Publisher Copyright: © 2022

PY - 2022

Y1 - 2022

N2 - High pathogenicity avian influenza viruses clade 2.3.4.4 H5 have spread among wild birds worldwide during recent years causing annual die-offs among wild birds and outbreaks in poultry in multiple European countries. The outbreaks significantly impact the poultry and game bird sectors. Infected game birds may act as a bridging species potentially enabling spread of virus into commercial and backyard premises. In this study, the pathogenesis and transmission of a HPAIV clade 2.3.4.4b H5N6 virus was investigated in pheasants and chickens. Efficient virus transmission was detected between pheasants over multiple rounds of naïve pheasant introductions and onwards to chickens. Mortality of up to 100% was observed for both infected pheasants and chickens. Intra-species transmission from chicken to chicken was less efficient. The study confirmed that clade 2.3.4.4b H5N6 HPAIV is highly virulent in pheasants and emphasises the role of pheasants as a bridging host for the infection of commercial poultry.

AB - High pathogenicity avian influenza viruses clade 2.3.4.4 H5 have spread among wild birds worldwide during recent years causing annual die-offs among wild birds and outbreaks in poultry in multiple European countries. The outbreaks significantly impact the poultry and game bird sectors. Infected game birds may act as a bridging species potentially enabling spread of virus into commercial and backyard premises. In this study, the pathogenesis and transmission of a HPAIV clade 2.3.4.4b H5N6 virus was investigated in pheasants and chickens. Efficient virus transmission was detected between pheasants over multiple rounds of naïve pheasant introductions and onwards to chickens. Mortality of up to 100% was observed for both infected pheasants and chickens. Intra-species transmission from chicken to chicken was less efficient. The study confirmed that clade 2.3.4.4b H5N6 HPAIV is highly virulent in pheasants and emphasises the role of pheasants as a bridging host for the infection of commercial poultry.

KW - Avian

KW - Chicken

KW - Epidemic

KW - Game bird

KW - HPAIV

KW - Influenza

KW - Pathogenesis

KW - Pheasant

KW - Transmission

U2 - 10.1016/j.virol.2022.10.009

DO - 10.1016/j.virol.2022.10.009

M3 - Journal article

C2 - 36371872

AN - SCOPUS:85141782539

VL - 577

SP - 138

EP - 148

JO - Virology

JF - Virology

SN - 0042-6822

ER -

ID: 330917342