THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS): REFERENCE INTERVALS AND EFFECTS OF STORAGE

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Standard

THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS) : REFERENCE INTERVALS AND EFFECTS OF STORAGE. / Perrin, Kathryn L.; Krogh, Anne K.; Kjelgaard-Hansen, Mads; Howard, Lauren; Bochsen, Louise; Kiso, Wendy K.; Schmitt, Dennis; Kristensen, Annemarie T.; Bertelsen, Mads F.

I: Journal of Zoo and Wildlife Medicine, Bind 49, Nr. 1, 03.2018, s. 54-63.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Perrin, KL, Krogh, AK, Kjelgaard-Hansen, M, Howard, L, Bochsen, L, Kiso, WK, Schmitt, D, Kristensen, AT & Bertelsen, MF 2018, 'THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS): REFERENCE INTERVALS AND EFFECTS OF STORAGE', Journal of Zoo and Wildlife Medicine, bind 49, nr. 1, s. 54-63. https://doi.org/10.1638/2017-0179R.1

APA

Perrin, K. L., Krogh, A. K., Kjelgaard-Hansen, M., Howard, L., Bochsen, L., Kiso, W. K., Schmitt, D., Kristensen, A. T., & Bertelsen, M. F. (2018). THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS): REFERENCE INTERVALS AND EFFECTS OF STORAGE. Journal of Zoo and Wildlife Medicine, 49(1), 54-63. https://doi.org/10.1638/2017-0179R.1

Vancouver

Perrin KL, Krogh AK, Kjelgaard-Hansen M, Howard L, Bochsen L, Kiso WK o.a. THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS): REFERENCE INTERVALS AND EFFECTS OF STORAGE. Journal of Zoo and Wildlife Medicine. 2018 mar.;49(1):54-63. https://doi.org/10.1638/2017-0179R.1

Author

Perrin, Kathryn L. ; Krogh, Anne K. ; Kjelgaard-Hansen, Mads ; Howard, Lauren ; Bochsen, Louise ; Kiso, Wendy K. ; Schmitt, Dennis ; Kristensen, Annemarie T. ; Bertelsen, Mads F. / THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS) : REFERENCE INTERVALS AND EFFECTS OF STORAGE. I: Journal of Zoo and Wildlife Medicine. 2018 ; Bind 49, Nr. 1. s. 54-63.

Bibtex

@article{b45cc6515e764ad9a65f7f7052e89e3b,
title = "THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS): REFERENCE INTERVALS AND EFFECTS OF STORAGE",
abstract = "Hemorrhagic disease associated with elephant endotheliotropic herpesvirus infection is the most-frequent cause of mortality in captive Asian elephants (Elephas maximus). Survival relies on intensive monitoring of hemostatic status. Thromboelastography (TEG) utilizes whole blood samples containing all the blood components of hemostasis and is therefore a sensitive indicator of the clinical status in the patient. This study was performed to assess the practicability of TEG in Asian elephants in a zoo environment. Citrated stabilized whole blood samples were obtained from 44 healthy Asian elephants. Kaolin-activated TEG was performed on whole blood at 60 min and 24 hr postsampling (to replicate shipment to an external laboratory) as well as on freeze–thawed plasma samples, 12–14 mo postsampling. Reference intervals were calculated for fresh whole blood and freeze–thawed plasma samples. In the 24-hr analysis, storage artifacts, likely due to cellular degeneration, resulted in a hypercoagulable thromboelastogram and thus reduced sensitivity for detecting coagulopathies. Therefore, delayed analysis of whole blood samples is not recommended.",
keywords = "Asian elephant, coagulation, Elephas maximus, hemostasis, thromboelastography",
author = "Perrin, {Kathryn L.} and Krogh, {Anne K.} and Mads Kjelgaard-Hansen and Lauren Howard and Louise Bochsen and Kiso, {Wendy K.} and Dennis Schmitt and Kristensen, {Annemarie T.} and Bertelsen, {Mads F.}",
year = "2018",
month = mar,
doi = "10.1638/2017-0179R.1",
language = "English",
volume = "49",
pages = "54--63",
journal = "Journal of Zoo and Wildlife Medicine",
issn = "1042-7260",
publisher = "American Association of Zoo Veterinarians",
number = "1",

}

RIS

TY - JOUR

T1 - THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT (ELEPHAS MAXIMUS)

T2 - REFERENCE INTERVALS AND EFFECTS OF STORAGE

AU - Perrin, Kathryn L.

AU - Krogh, Anne K.

AU - Kjelgaard-Hansen, Mads

AU - Howard, Lauren

AU - Bochsen, Louise

AU - Kiso, Wendy K.

AU - Schmitt, Dennis

AU - Kristensen, Annemarie T.

AU - Bertelsen, Mads F.

PY - 2018/3

Y1 - 2018/3

N2 - Hemorrhagic disease associated with elephant endotheliotropic herpesvirus infection is the most-frequent cause of mortality in captive Asian elephants (Elephas maximus). Survival relies on intensive monitoring of hemostatic status. Thromboelastography (TEG) utilizes whole blood samples containing all the blood components of hemostasis and is therefore a sensitive indicator of the clinical status in the patient. This study was performed to assess the practicability of TEG in Asian elephants in a zoo environment. Citrated stabilized whole blood samples were obtained from 44 healthy Asian elephants. Kaolin-activated TEG was performed on whole blood at 60 min and 24 hr postsampling (to replicate shipment to an external laboratory) as well as on freeze–thawed plasma samples, 12–14 mo postsampling. Reference intervals were calculated for fresh whole blood and freeze–thawed plasma samples. In the 24-hr analysis, storage artifacts, likely due to cellular degeneration, resulted in a hypercoagulable thromboelastogram and thus reduced sensitivity for detecting coagulopathies. Therefore, delayed analysis of whole blood samples is not recommended.

AB - Hemorrhagic disease associated with elephant endotheliotropic herpesvirus infection is the most-frequent cause of mortality in captive Asian elephants (Elephas maximus). Survival relies on intensive monitoring of hemostatic status. Thromboelastography (TEG) utilizes whole blood samples containing all the blood components of hemostasis and is therefore a sensitive indicator of the clinical status in the patient. This study was performed to assess the practicability of TEG in Asian elephants in a zoo environment. Citrated stabilized whole blood samples were obtained from 44 healthy Asian elephants. Kaolin-activated TEG was performed on whole blood at 60 min and 24 hr postsampling (to replicate shipment to an external laboratory) as well as on freeze–thawed plasma samples, 12–14 mo postsampling. Reference intervals were calculated for fresh whole blood and freeze–thawed plasma samples. In the 24-hr analysis, storage artifacts, likely due to cellular degeneration, resulted in a hypercoagulable thromboelastogram and thus reduced sensitivity for detecting coagulopathies. Therefore, delayed analysis of whole blood samples is not recommended.

KW - Asian elephant

KW - coagulation

KW - Elephas maximus

KW - hemostasis

KW - thromboelastography

U2 - 10.1638/2017-0179R.1

DO - 10.1638/2017-0179R.1

M3 - Journal article

C2 - 29517458

VL - 49

SP - 54

EP - 63

JO - Journal of Zoo and Wildlife Medicine

JF - Journal of Zoo and Wildlife Medicine

SN - 1042-7260

IS - 1

ER -

ID: 194524370