Clinicopathologic evaluation of congenital idiopathic megaesophagus in a Gordon Setter puppy: a case report and development and application of peripherin immunohistochemistry for detection of ganglion cells
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Clinicopathologic evaluation of congenital idiopathic megaesophagus in a Gordon Setter puppy : a case report and development and application of peripherin immunohistochemistry for detection of ganglion cells. / Becker, Cecilie B.; Jensen, Henrik E.
I: Journal of Veterinary Diagnostic Investigation, Bind 36, Nr. 2, 2024, s. 254-257.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Clinicopathologic evaluation of congenital idiopathic megaesophagus in a Gordon Setter puppy
T2 - a case report and development and application of peripherin immunohistochemistry for detection of ganglion cells
AU - Becker, Cecilie B.
AU - Jensen, Henrik E.
N1 - Publisher Copyright: © 2024 The Author(s).
PY - 2024
Y1 - 2024
N2 - We examined a case of congenital idiopathic megaesophagus (CIM) in a 5-wk-old female Gordon Setter puppy by means of contrast radiography, autopsy, histopathology, and immunohistochemistry. Clinical and radiologic findings included weight stagnation and marked generalized esophageal dilation with ventral displacement of the heart and lungs. These findings were confirmed at autopsy, and segments of the thoracic esophagus were sampled for histopathology. On histopathology, diffuse esophageal muscular atrophy, mucosal erosions, mononuclear inflammation, and a marked reduction in the number of myenteric plexus structures and number of ganglion cells were present (aganglionosis). The latter was determined immunohistochemically using an anti-peripherin antibody as the primary reagent, which provides a strong tool for the histologic confirmation of CIM. The histologic findings share some similarities to lesions associated with megaesophagus in Friesian foals, as well as esophageal achalasia and Hirschsprung disease in humans.
AB - We examined a case of congenital idiopathic megaesophagus (CIM) in a 5-wk-old female Gordon Setter puppy by means of contrast radiography, autopsy, histopathology, and immunohistochemistry. Clinical and radiologic findings included weight stagnation and marked generalized esophageal dilation with ventral displacement of the heart and lungs. These findings were confirmed at autopsy, and segments of the thoracic esophagus were sampled for histopathology. On histopathology, diffuse esophageal muscular atrophy, mucosal erosions, mononuclear inflammation, and a marked reduction in the number of myenteric plexus structures and number of ganglion cells were present (aganglionosis). The latter was determined immunohistochemically using an anti-peripherin antibody as the primary reagent, which provides a strong tool for the histologic confirmation of CIM. The histologic findings share some similarities to lesions associated with megaesophagus in Friesian foals, as well as esophageal achalasia and Hirschsprung disease in humans.
KW - aganglionosis
KW - Gordon Setter
KW - immunohistochemistry
KW - megaesophagus
KW - pathology
KW - peripherin
U2 - 10.1177/10406387241226950
DO - 10.1177/10406387241226950
M3 - Journal article
C2 - 38305240
AN - SCOPUS:85184257138
VL - 36
SP - 254
EP - 257
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
IS - 2
ER -
ID: 385650224