Effects of dietary vegetable oils on mammary lipid-related genes in holstein dairy cows
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Effects of dietary vegetable oils on mammary lipid-related genes in holstein dairy cows. / Vargas-Bello-pérez, Einar; Geldsetzer-Mendoza, Carolina; Cancino-Padilla, Nathaly; Morales, María Sol; Leskinen, Heidi; Garnsworthy, Philip C.; Loor, Juan J.; Romero, Jaime.
I: Animals, Bind 10, Nr. 1, 57, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of dietary vegetable oils on mammary lipid-related genes in holstein dairy cows
AU - Vargas-Bello-pérez, Einar
AU - Geldsetzer-Mendoza, Carolina
AU - Cancino-Padilla, Nathaly
AU - Morales, María Sol
AU - Leskinen, Heidi
AU - Garnsworthy, Philip C.
AU - Loor, Juan J.
AU - Romero, Jaime
PY - 2020
Y1 - 2020
N2 - This study analyzed effects of vegetable oils fed to dairy cows on abundance of genes related to lipid metabolism in milk somatic cells (MSC). During 63 days, 15 cows were allocated to 3 treatments: a control diet with no added lipid the same diet supplemented with olive oil (OO, 30 g/kg DM) or hydrogenated vegetable oil (HVO, 30 g/kg DM). On days 21, 42 and 63, MSC were obtained from all cows. Relative abundance of genes involved in lipid metabolism in MSC from cows fed control on days 42 and 63 was compared with relative abundance at day 21 to evaluate fold-changes. Those genes without changes over the time were selected to analyze effects of OO and HVO. Compared with control, on day 42, PLIN2 and THRSP were upregulated by OO. Compared with control, on day 21, HVO up regulated ACACA, down regulated FABP3, and on day 63 THRSP and FABP4 were down regulated. Dietary oil supplementation (3% DM) had a modest nutrigenomic effect on different biological functions such as acetate and FA activation and intra-cellular transport, lipid droplet formation, and transcription regulation in MSC.
AB - This study analyzed effects of vegetable oils fed to dairy cows on abundance of genes related to lipid metabolism in milk somatic cells (MSC). During 63 days, 15 cows were allocated to 3 treatments: a control diet with no added lipid the same diet supplemented with olive oil (OO, 30 g/kg DM) or hydrogenated vegetable oil (HVO, 30 g/kg DM). On days 21, 42 and 63, MSC were obtained from all cows. Relative abundance of genes involved in lipid metabolism in MSC from cows fed control on days 42 and 63 was compared with relative abundance at day 21 to evaluate fold-changes. Those genes without changes over the time were selected to analyze effects of OO and HVO. Compared with control, on day 42, PLIN2 and THRSP were upregulated by OO. Compared with control, on day 21, HVO up regulated ACACA, down regulated FABP3, and on day 63 THRSP and FABP4 were down regulated. Dietary oil supplementation (3% DM) had a modest nutrigenomic effect on different biological functions such as acetate and FA activation and intra-cellular transport, lipid droplet formation, and transcription regulation in MSC.
KW - Gene abundance
KW - Mammary gland
KW - Milk somatic cells
KW - Olive oil
KW - Transcriptomic
U2 - 10.3390/ani10010057
DO - 10.3390/ani10010057
M3 - Journal article
C2 - 31892210
AN - SCOPUS:85077385525
VL - 10
JO - Animals
JF - Animals
SN - 2076-2615
IS - 1
M1 - 57
ER -
ID: 234210218