Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants.

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Standard

Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants. / McCahon, D.; Crowther, J. R.; Belsham, G. J.; Kitson, J. D.; Duchesne, M.; Have, P.; Meloen, R. H.; Morgan, D. O.; De Simone, F.

I: The Journal of general virology, Bind 70 ( Pt 3), 03.1989, s. 639-645.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

McCahon, D, Crowther, JR, Belsham, GJ, Kitson, JD, Duchesne, M, Have, P, Meloen, RH, Morgan, DO & De Simone, F 1989, 'Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants.', The Journal of general virology, bind 70 ( Pt 3), s. 639-645. https://doi.org/10.1099/0022-1317-70-3-639

APA

McCahon, D., Crowther, J. R., Belsham, G. J., Kitson, J. D., Duchesne, M., Have, P., Meloen, R. H., Morgan, D. O., & De Simone, F. (1989). Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants. The Journal of general virology, 70 ( Pt 3), 639-645. https://doi.org/10.1099/0022-1317-70-3-639

Vancouver

McCahon D, Crowther JR, Belsham GJ, Kitson JD, Duchesne M, Have P o.a. Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants. The Journal of general virology. 1989 mar.;70 ( Pt 3):639-645. https://doi.org/10.1099/0022-1317-70-3-639

Author

McCahon, D. ; Crowther, J. R. ; Belsham, G. J. ; Kitson, J. D. ; Duchesne, M. ; Have, P. ; Meloen, R. H. ; Morgan, D. O. ; De Simone, F. / Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants. I: The Journal of general virology. 1989 ; Bind 70 ( Pt 3). s. 639-645.

Bibtex

@article{06bb8708baf341508b90dfd562fee72d,
title = "Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants.",
abstract = "Neutralizing monoclonal antibodies raised against type O foot-and-mouth disease virus have been characterized on the basis of their reactivity with a panel of single site monoclonal antibody-resistant mutants which had defined three antigenic sites. Five antibodies neutralized all these mutants, but by selecting further single site mutants with one of these antibodies it was possible to define a fourth site involved in virus neutralization. Two monoclonal antibodies still neutralized these mutants and all multiple site resistant mutants. One multiple site resistant mutant was resistant to neutralization at each of four antigenic sites but was still efficiently neutralized by type O convalescent cattle sera. The relationship between sites recognized by different monoclonal antibodies generated in different laboratories is discussed.",
author = "D. McCahon and Crowther, {J. R.} and Belsham, {G. J.} and Kitson, {J. D.} and M. Duchesne and P. Have and Meloen, {R. H.} and Morgan, {D. O.} and {De Simone}, F.",
year = "1989",
month = mar,
doi = "10.1099/0022-1317-70-3-639",
language = "English",
volume = "70 ( Pt 3)",
pages = "639--645",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",

}

RIS

TY - JOUR

T1 - Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants.

AU - McCahon, D.

AU - Crowther, J. R.

AU - Belsham, G. J.

AU - Kitson, J. D.

AU - Duchesne, M.

AU - Have, P.

AU - Meloen, R. H.

AU - Morgan, D. O.

AU - De Simone, F.

PY - 1989/3

Y1 - 1989/3

N2 - Neutralizing monoclonal antibodies raised against type O foot-and-mouth disease virus have been characterized on the basis of their reactivity with a panel of single site monoclonal antibody-resistant mutants which had defined three antigenic sites. Five antibodies neutralized all these mutants, but by selecting further single site mutants with one of these antibodies it was possible to define a fourth site involved in virus neutralization. Two monoclonal antibodies still neutralized these mutants and all multiple site resistant mutants. One multiple site resistant mutant was resistant to neutralization at each of four antigenic sites but was still efficiently neutralized by type O convalescent cattle sera. The relationship between sites recognized by different monoclonal antibodies generated in different laboratories is discussed.

AB - Neutralizing monoclonal antibodies raised against type O foot-and-mouth disease virus have been characterized on the basis of their reactivity with a panel of single site monoclonal antibody-resistant mutants which had defined three antigenic sites. Five antibodies neutralized all these mutants, but by selecting further single site mutants with one of these antibodies it was possible to define a fourth site involved in virus neutralization. Two monoclonal antibodies still neutralized these mutants and all multiple site resistant mutants. One multiple site resistant mutant was resistant to neutralization at each of four antigenic sites but was still efficiently neutralized by type O convalescent cattle sera. The relationship between sites recognized by different monoclonal antibodies generated in different laboratories is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0000756795&partnerID=8YFLogxK

U2 - 10.1099/0022-1317-70-3-639

DO - 10.1099/0022-1317-70-3-639

M3 - Journal article

C2 - 2471793

AN - SCOPUS:0000756795

VL - 70 ( Pt 3)

SP - 639

EP - 645

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

ER -

ID: 381228855