Gut microbiota maturity mediates the protective effect of siblings on food allergy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota. Objective: We sought to investigate whether having older siblings decreases the risk of IgE-mediated food allergy by accelerating the maturation of the infant gut microbiota. Methods: In a birth cohort assembled using an unselected antenatal sampling frame (n = 1074), fecal samples were collected at 1 month, 6 months, and 1 year, and food allergy status at 1 year was determined by skin prick test and in-hospital food challenge. We used 16S rRNA gene amplicon sequencing to derive amplicon sequence variants. Among a random subcohort (n = 323), microbiota-by-age z scores at each time point were calculated using fecal amplicon sequence variants to represent the gut microbiota maturation over the first year of life. Results: A greater number of siblings was associated with a higher microbiota-by-age z score at age 1 year (β = 0.15 per an additional sibling; 95% CI, 0.05-0.24; P = .003), which was in turn associated with decreased odds of food allergy (odds ratio, 0.45; 95% CI, 0.33-0.61; P < .001). Microbiota-by-age z scores mediated 63% of the protective effect of siblings. Analogous associations were not observed at younger ages. Conclusions: The protective effect of older siblings on the risk of developing IgE-mediated food allergy during infancy is substantially mediated by advanced maturation of the gut microbiota at age 1 year.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Allergy and Clinical Immunology |
Vol/bind | 152 |
Udgave nummer | 3 |
Sider (fra-til) | 667-675 |
Antal sider | 9 |
ISSN | 0091-6749 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This study was funded by the National Health and Medical Research Council of Australia (grant nos. 1082307 and 1147980), the Australian Food Allergy Foundation , The Murdoch Children’s Research Institute, Barwon Health, and Deakin University .
Publisher Copyright:
© 2023 American Academy of Allergy, Asthma & Immunology
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