In vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence
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In vitro production of bovine embryos : Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence. / Mazzoni, Gianluca; Razza, Eduardo; Pedersen, Hanne S.; Secher, Jan; Kadarmideen, Haja N.; Callesen, Henrik; Stroebech, Lotte; Freude, Kristine; Hyttel, Poul.
I: Animal Reproduction, Bind 14, Nr. 3, 2017, s. 482-489.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - In vitro production of bovine embryos
T2 - Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence
AU - Mazzoni, Gianluca
AU - Razza, Eduardo
AU - Pedersen, Hanne S.
AU - Secher, Jan
AU - Kadarmideen, Haja N.
AU - Callesen, Henrik
AU - Stroebech, Lotte
AU - Freude, Kristine
AU - Hyttel, Poul
PY - 2017
Y1 - 2017
N2 - In vitro production (IVP) of bovine embryos has become widespread technology implemented in cattle breeding and production. Here, we review novel data on cumulus/granulosa cell gene expression, as determined by RNAseq on cellular material from pooled follicular fluids at the single animal level, and relate these finding to previous data on oocyte developmental competence and ultrastructure. The cumulus/granulosa cell gene expression patterns indicate that early follicular atresia is associated with increased blastocyst yield and this hypothesis is supported by previous data on oocyte competence and ultrastructure.
AB - In vitro production (IVP) of bovine embryos has become widespread technology implemented in cattle breeding and production. Here, we review novel data on cumulus/granulosa cell gene expression, as determined by RNAseq on cellular material from pooled follicular fluids at the single animal level, and relate these finding to previous data on oocyte developmental competence and ultrastructure. The cumulus/granulosa cell gene expression patterns indicate that early follicular atresia is associated with increased blastocyst yield and this hypothesis is supported by previous data on oocyte competence and ultrastructure.
KW - Atresia
KW - Biomarkers
KW - Cattle
KW - Granulosa cells
KW - IVP
KW - Oocyte competence
KW - Transcriptomics
U2 - 10.21451/1984-3143-AR990
DO - 10.21451/1984-3143-AR990
M3 - Journal article
AN - SCOPUS:85044511925
VL - 14
SP - 482
EP - 489
JO - Animal Reproduction
JF - Animal Reproduction
SN - 1806-9614
IS - 3
ER -
ID: 195975370