Nickel allergy and relationship with Staphylococcus aureus in atopic dermatitis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Nickel allergy and relationship with Staphylococcus aureus in atopic dermatitis. / Anna, Bogdali M.; Grazyna, Antoszczyk; Wojciech, Dyga; Aleksander, Obtulowicz; Anna, Bialecka; Andrzej, Kasprowicz; Magnowska, Zofia; Krystyna, Obtulowicz.
I: Journal of Trace Elements in Medicine and Biology, Bind 33, 01.01.2016, s. 1-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Nickel allergy and relationship with Staphylococcus aureus in atopic dermatitis
AU - Anna, Bogdali M.
AU - Grazyna, Antoszczyk
AU - Wojciech, Dyga
AU - Aleksander, Obtulowicz
AU - Anna, Bialecka
AU - Andrzej, Kasprowicz
AU - Magnowska, Zofia
AU - Krystyna, Obtulowicz
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: The increase of nickel air pollution is supposed to frequent side effects of nickel action related to virulence potential of Staphylococcus aureus in patients with nickel allergy in atopic dermatitis. The goal was to investigate the relationship between nickel allergy and infection by S. aureus in atopic dermatitis. Methods: Nickel allergy was confirmed in atopic patients and excluded in healthy volunteers using patch testing. Infection by S. aureus was tested in atopic patients and healthy volunteers by use of API Staph system. The specific IgE for staphylococcal enterotoxin A and B were measured. Secretion of IFN-g, IL-2, IL-13 by PBMC under nickel sulfate and the enterotoxins A and B stimulations were studied with ELISpot. Results: We found the increased number of infections by S. aureus in atopic patients with nickel allergy in comparison to atopic patients and healthy volunteers without nickel allergy. The elevated secretion of IL-2 under nickel sulfate stimulation in vitro was exclusively found in atopic patients with nickel allergy infected by S. aureus. Conclusions: Our data suggest that nickel allergy and infection by S. aureus are linked in atopic dermatitis.
AB - Background: The increase of nickel air pollution is supposed to frequent side effects of nickel action related to virulence potential of Staphylococcus aureus in patients with nickel allergy in atopic dermatitis. The goal was to investigate the relationship between nickel allergy and infection by S. aureus in atopic dermatitis. Methods: Nickel allergy was confirmed in atopic patients and excluded in healthy volunteers using patch testing. Infection by S. aureus was tested in atopic patients and healthy volunteers by use of API Staph system. The specific IgE for staphylococcal enterotoxin A and B were measured. Secretion of IFN-g, IL-2, IL-13 by PBMC under nickel sulfate and the enterotoxins A and B stimulations were studied with ELISpot. Results: We found the increased number of infections by S. aureus in atopic patients with nickel allergy in comparison to atopic patients and healthy volunteers without nickel allergy. The elevated secretion of IL-2 under nickel sulfate stimulation in vitro was exclusively found in atopic patients with nickel allergy infected by S. aureus. Conclusions: Our data suggest that nickel allergy and infection by S. aureus are linked in atopic dermatitis.
KW - Atopic
KW - Dermatitis
KW - Nickel
U2 - 10.1016/j.jtemb.2015.06.009
DO - 10.1016/j.jtemb.2015.06.009
M3 - Journal article
C2 - 26653736
AN - SCOPUS:84951054198
VL - 33
SP - 1
EP - 7
JO - Journal of Trace Elements in Medicine and Biology
JF - Journal of Trace Elements in Medicine and Biology
SN - 0946-672X
ER -
ID: 179045817