Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

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Standard

Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model. / Grell, Susanne N.; Riber, Ulla; Tjørnehøj, Kirsten; Larsen, Lars E.; Heegaard, Peter M.H.

I: Vaccine, Bind 23, Nr. 26, 16.05.2005, s. 3412-3423.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Grell, SN, Riber, U, Tjørnehøj, K, Larsen, LE & Heegaard, PMH 2005, 'Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model', Vaccine, bind 23, nr. 26, s. 3412-3423. https://doi.org/10.1016/j.vaccine.2005.01.094

APA

Grell, S. N., Riber, U., Tjørnehøj, K., Larsen, L. E., & Heegaard, P. M. H. (2005). Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model. Vaccine, 23(26), 3412-3423. https://doi.org/10.1016/j.vaccine.2005.01.094

Vancouver

Grell SN, Riber U, Tjørnehøj K, Larsen LE, Heegaard PMH. Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model. Vaccine. 2005 maj 16;23(26):3412-3423. https://doi.org/10.1016/j.vaccine.2005.01.094

Author

Grell, Susanne N. ; Riber, Ulla ; Tjørnehøj, Kirsten ; Larsen, Lars E. ; Heegaard, Peter M.H. / Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model. I: Vaccine. 2005 ; Bind 23, Nr. 26. s. 3412-3423.

Bibtex

@article{479810ae0208432b8ac7ea08ffc18bbb,
title = "Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model",
abstract = "Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFα levels and less virus-specific IFNγ release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong {"} inflammatory{"} but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.",
keywords = "Age-dependent immunity, Bovine respiratory syncytial virus",
author = "Grell, {Susanne N.} and Ulla Riber and Kirsten Tj{\o}rneh{\o}j and Larsen, {Lars E.} and Heegaard, {Peter M.H.}",
year = "2005",
month = may,
day = "16",
doi = "10.1016/j.vaccine.2005.01.094",
language = "English",
volume = "23",
pages = "3412--3423",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "26",

}

RIS

TY - JOUR

T1 - Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model

AU - Grell, Susanne N.

AU - Riber, Ulla

AU - Tjørnehøj, Kirsten

AU - Larsen, Lars E.

AU - Heegaard, Peter M.H.

PY - 2005/5/16

Y1 - 2005/5/16

N2 - Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFα levels and less virus-specific IFNγ release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong " inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.

AB - Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFα levels and less virus-specific IFNγ release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong " inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.

KW - Age-dependent immunity

KW - Bovine respiratory syncytial virus

U2 - 10.1016/j.vaccine.2005.01.094

DO - 10.1016/j.vaccine.2005.01.094

M3 - Journal article

C2 - 15837365

AN - SCOPUS:17144409375

VL - 23

SP - 3412

EP - 3423

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 26

ER -

ID: 247400350