Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses

Institut for Veterinær- og Husdyrvidenskab

Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses. / Ryt-Hansen, Pia; Krog, Jesper Schak; Breum, Solvej Østergaard; Hjulsager, Charlotte Kristiane; Pedersen, Anders Gorm; Trebbien, Ramona; Larsen, Lars Erik.

I: eLife, Bind 10, e60940, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ryt-Hansen, P, Krog, JS, Breum, SØ, Hjulsager, CK, Pedersen, AG, Trebbien, R & Larsen, LE 2021, 'Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses', eLife, bind 10, e60940. https://doi.org/10.7554/eLife.60940

APA

Ryt-Hansen, P., Krog, J. S., Breum, S. Ø., Hjulsager, C. K., Pedersen, A. G., Trebbien, R., & Larsen, L. E. (2021). Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses. eLife, 10, [e60940]. https://doi.org/10.7554/eLife.60940

Vancouver

Ryt-Hansen P, Krog JS, Breum SØ, Hjulsager CK, Pedersen AG, Trebbien R o.a. Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses. eLife. 2021;10. e60940. https://doi.org/10.7554/eLife.60940

Author

Ryt-Hansen, Pia ; Krog, Jesper Schak ; Breum, Solvej Østergaard ; Hjulsager, Charlotte Kristiane ; Pedersen, Anders Gorm ; Trebbien, Ramona ; Larsen, Lars Erik. / Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses. I: eLife. 2021 ; Bind 10.

Bibtex

@article{d8e5675cbc644cc1ae260412098b0225,

title = "Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses",

abstract = "Since the influenza pandemic in 2009, there has been an increased focus on swine influenza A virus (swIAV) surveillance. This paper describes the results of the surveillance of swIAV in Danish swine from 2011 to 2018. In total, 3800 submissions were received with a steady increase in swIAV positive submissions, reaching 56% in 2018. Full genome sequences were obtained from 129 swIAV positive samples. Altogether, 17 different circulating genotypes were identified including six novel reassortants harboring human seasonal IAV gene segments. The phylogenetic analysis revealed substantial genetic drift and also evidence of positive selection occurring mainly in antigenic sites of the hemagglutinin protein and confirmed the presence of a swine divergent cluster among the H lpdm09Nx (clade 1 A.3.3.2) viruses. The results provide essential data for the control of swIAV in pigs and emphasize the importance of contemporary surveillance for discovering novel swIAV strains posing a potential threat to the human population.",

author = "Pia Ryt-Hansen and Krog, {Jesper Schak} and Breum, {Solvej {\O}stergaard} and Hjulsager, {Charlotte Kristiane} and Pedersen, {Anders Gorm} and Ramona Trebbien and Larsen, {Lars Erik}",

year = "2021",

doi = "10.7554/eLife.60940",

language = "English",

volume = "10",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - Co-circulation of multiple influenza a reassortants in swine harboring genes from seasonal human and swine influenza viruses

AU - Ryt-Hansen, Pia

AU - Krog, Jesper Schak

AU - Breum, Solvej Østergaard

AU - Hjulsager, Charlotte Kristiane

AU - Pedersen, Anders Gorm

AU - Trebbien, Ramona

AU - Larsen, Lars Erik

PY - 2021

Y1 - 2021

N2 - Since the influenza pandemic in 2009, there has been an increased focus on swine influenza A virus (swIAV) surveillance. This paper describes the results of the surveillance of swIAV in Danish swine from 2011 to 2018. In total, 3800 submissions were received with a steady increase in swIAV positive submissions, reaching 56% in 2018. Full genome sequences were obtained from 129 swIAV positive samples. Altogether, 17 different circulating genotypes were identified including six novel reassortants harboring human seasonal IAV gene segments. The phylogenetic analysis revealed substantial genetic drift and also evidence of positive selection occurring mainly in antigenic sites of the hemagglutinin protein and confirmed the presence of a swine divergent cluster among the H lpdm09Nx (clade 1 A.3.3.2) viruses. The results provide essential data for the control of swIAV in pigs and emphasize the importance of contemporary surveillance for discovering novel swIAV strains posing a potential threat to the human population.

AB - Since the influenza pandemic in 2009, there has been an increased focus on swine influenza A virus (swIAV) surveillance. This paper describes the results of the surveillance of swIAV in Danish swine from 2011 to 2018. In total, 3800 submissions were received with a steady increase in swIAV positive submissions, reaching 56% in 2018. Full genome sequences were obtained from 129 swIAV positive samples. Altogether, 17 different circulating genotypes were identified including six novel reassortants harboring human seasonal IAV gene segments. The phylogenetic analysis revealed substantial genetic drift and also evidence of positive selection occurring mainly in antigenic sites of the hemagglutinin protein and confirmed the presence of a swine divergent cluster among the H lpdm09Nx (clade 1 A.3.3.2) viruses. The results provide essential data for the control of swIAV in pigs and emphasize the importance of contemporary surveillance for discovering novel swIAV strains posing a potential threat to the human population.

U2 - 10.7554/eLife.60940

DO - 10.7554/eLife.60940

M3 - Journal article

C2 - 34313225

AN - SCOPUS:85111842611

VL - 10

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e60940

ER -

ID: 280181229