Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring : results of a randomised, placebo-controlled trial. / Tweyongyere, Robert; Mawa, Patrice A.; Kihembo, Macklyn; Jones, Frances M.; Webb, Emily L.; Cose, Stephen; Dunne, David W.; Vennervald, Birgitte J; Elliott, Alison M.
I: B M C Infectious Diseases, Bind 11, Nr. 234, 2011.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring
T2 - results of a randomised, placebo-controlled trial
AU - Tweyongyere, Robert
AU - Mawa, Patrice A.
AU - Kihembo, Macklyn
AU - Jones, Frances M.
AU - Webb, Emily L.
AU - Cose, Stephen
AU - Dunne, David W.
AU - Vennervald, Birgitte J
AU - Elliott, Alison M.
PY - 2011
Y1 - 2011
N2 - Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown.
AB - Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown.
KW - Animals
KW - Antibodies, Protozoan
KW - Antigens, Protozoan
KW - Antiprotozoal Agents
KW - Cytokines
KW - Female
KW - Humans
KW - Immunity, Maternally-Acquired
KW - Infant
KW - Infant, Newborn
KW - Leukocytes, Mononuclear
KW - Placebos
KW - Praziquantel
KW - Pregnancy
KW - Pregnancy Complications, Parasitic
KW - Schistosoma mansoni
KW - Schistosomiasis mansoni
KW - Treatment Outcome
KW - Uganda
U2 - 10.1186/1471-2334-11-234
DO - 10.1186/1471-2334-11-234
M3 - Journal article
C2 - 21888656
VL - 11
JO - B M C Infectious Diseases
JF - B M C Infectious Diseases
SN - 1471-2334
IS - 234
ER -
ID: 36091168