Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1)

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Standard

Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1). / Lademann, Ulrik Axel; Rømer, Maria Unni Koefoed.

I: Thrombosis and Haemostasis, Bind 100, Nr. 6, 2008, s. 1041-1046.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lademann, UA & Rømer, MUK 2008, 'Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1)', Thrombosis and Haemostasis, bind 100, nr. 6, s. 1041-1046. https://doi.org/10.1160/TH08-04-0266

APA

Lademann, U. A., & Rømer, M. U. K. (2008). Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1). Thrombosis and Haemostasis, 100(6), 1041-1046. https://doi.org/10.1160/TH08-04-0266

Vancouver

Lademann UA, Rømer MUK. Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1). Thrombosis and Haemostasis. 2008;100(6):1041-1046. https://doi.org/10.1160/TH08-04-0266

Author

Lademann, Ulrik Axel ; Rømer, Maria Unni Koefoed. / Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1). I: Thrombosis and Haemostasis. 2008 ; Bind 100, Nr. 6. s. 1041-1046.

Bibtex

@article{beaf8930c77c11dd9473000ea68e967b,
title = "Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1)",
abstract = "Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with poor prognosis in cancer. An explanation to the elevated levels of PAI-1 could be a protective response to the increased proteolytic activity, caused by elevated levels of urokinase- type plasminogen activator (uPA) observed in tumours; however, several lines of evidence suggest that PAI-1 may contribute directly to the pathology of the disease. PAI-1 has been reported to have an effect on most of the basic cellular processes including cell adhesion, cell migration, cell invasion, and cell proliferation and increasing numbers of reports suggest that PAI-1 also can regulate programmed cell death (PCD) in cancer cells and normal cells. A number of reports suggest that PAI-1 can inhibit PCD through its pro-adhesive/anti-proteolytic property whereas other reports suggest that PAI-1 induces PCD through its anti-adhesive property.Furthermore,it has been suggested that PAI-1 can either induce or inhibit PCD though activation of cell signalling pathways.This review will focus on the regulation of programmed cell death by PAI-1 in both normal cells and cancer cells.",
keywords = "Former Faculty of Life Sciences",
author = "Lademann, {Ulrik Axel} and R{\o}mer, {Maria Unni Koefoed}",
year = "2008",
doi = "10.1160/TH08-04-0266",
language = "English",
volume = "100",
pages = "1041--1046",
journal = "Thrombosis et diathesis haemorrhagica",
issn = "0340-6245",
publisher = "Schattauer",
number = "6",

}

RIS

TY - JOUR

T1 - Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1)

AU - Lademann, Ulrik Axel

AU - Rømer, Maria Unni Koefoed

PY - 2008

Y1 - 2008

N2 - Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with poor prognosis in cancer. An explanation to the elevated levels of PAI-1 could be a protective response to the increased proteolytic activity, caused by elevated levels of urokinase- type plasminogen activator (uPA) observed in tumours; however, several lines of evidence suggest that PAI-1 may contribute directly to the pathology of the disease. PAI-1 has been reported to have an effect on most of the basic cellular processes including cell adhesion, cell migration, cell invasion, and cell proliferation and increasing numbers of reports suggest that PAI-1 also can regulate programmed cell death (PCD) in cancer cells and normal cells. A number of reports suggest that PAI-1 can inhibit PCD through its pro-adhesive/anti-proteolytic property whereas other reports suggest that PAI-1 induces PCD through its anti-adhesive property.Furthermore,it has been suggested that PAI-1 can either induce or inhibit PCD though activation of cell signalling pathways.This review will focus on the regulation of programmed cell death by PAI-1 in both normal cells and cancer cells.

AB - Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with poor prognosis in cancer. An explanation to the elevated levels of PAI-1 could be a protective response to the increased proteolytic activity, caused by elevated levels of urokinase- type plasminogen activator (uPA) observed in tumours; however, several lines of evidence suggest that PAI-1 may contribute directly to the pathology of the disease. PAI-1 has been reported to have an effect on most of the basic cellular processes including cell adhesion, cell migration, cell invasion, and cell proliferation and increasing numbers of reports suggest that PAI-1 also can regulate programmed cell death (PCD) in cancer cells and normal cells. A number of reports suggest that PAI-1 can inhibit PCD through its pro-adhesive/anti-proteolytic property whereas other reports suggest that PAI-1 induces PCD through its anti-adhesive property.Furthermore,it has been suggested that PAI-1 can either induce or inhibit PCD though activation of cell signalling pathways.This review will focus on the regulation of programmed cell death by PAI-1 in both normal cells and cancer cells.

KW - Former Faculty of Life Sciences

U2 - 10.1160/TH08-04-0266

DO - 10.1160/TH08-04-0266

M3 - Journal article

VL - 100

SP - 1041

EP - 1046

JO - Thrombosis et diathesis haemorrhagica

JF - Thrombosis et diathesis haemorrhagica

SN - 0340-6245

IS - 6

ER -

ID: 9066371