Bacteriophage Moonlighting Proteins in the Control of Bacterial Pathogenicity
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning
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Bacteriophage Moonlighting Proteins in the Control of Bacterial Pathogenicity. / Bowring, Janine Z.; Marina, Alberto; Penadés, José R.; Quiles-Puchalt, Nuria.
Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections. Wiley-Blackwell, 2016. s. 387-412.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning
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TY - CHAP
T1 - Bacteriophage Moonlighting Proteins in the Control of Bacterial Pathogenicity
AU - Bowring, Janine Z.
AU - Marina, Alberto
AU - Penadés, José R.
AU - Quiles-Puchalt, Nuria
N1 - Publisher Copyright: © 2017 John Wiley & Sons, Inc.
PY - 2016/10/3
Y1 - 2016/10/3
N2 - This chapter describes the dual role of bacteria-encoded proteins along with their impact on the bacteriophage biology and the repercussion in bacterial pathogenicity. The use of bacteriophage-encoded proteins as de-repressor proteins is an elegant strategy that allows the Staphylococcus aureus pathogenicity islands (SaPI) to be induced only when the helper phage has entered the lytic cycle. The chapter examines the dual role of various well-known and well-characterized bacteriophage moonlighting proteins and their impact on bacterial pathogenicity. The first example of moonlighting proteins studied was the homing endonuclease T4 I-TevI encoded by the T4 bacteriophage. This homing endonuclease, in addition to its main cleavage activity, has a role as a transcriptional regulator controlling its own transfer. Understanding the biology of bacteriophages is of great importance due to their crucial role in bacterial pathogenicity, as well as for the study of the different proteins and functions that they have for their own biology.
AB - This chapter describes the dual role of bacteria-encoded proteins along with their impact on the bacteriophage biology and the repercussion in bacterial pathogenicity. The use of bacteriophage-encoded proteins as de-repressor proteins is an elegant strategy that allows the Staphylococcus aureus pathogenicity islands (SaPI) to be induced only when the helper phage has entered the lytic cycle. The chapter examines the dual role of various well-known and well-characterized bacteriophage moonlighting proteins and their impact on bacterial pathogenicity. The first example of moonlighting proteins studied was the homing endonuclease T4 I-TevI encoded by the T4 bacteriophage. This homing endonuclease, in addition to its main cleavage activity, has a role as a transcriptional regulator controlling its own transfer. Understanding the biology of bacteriophages is of great importance due to their crucial role in bacterial pathogenicity, as well as for the study of the different proteins and functions that they have for their own biology.
KW - Bacterial pathogenicity
KW - Bacteriophage moonlighting proteins
KW - Bacteriophage P4 functions
KW - Homing endonuclease T4 I-TevI
KW - Staphylococcus aureus pathogenicity islands
KW - T7 DNA polymerase
KW - Transcriptional autorepressor
UR - http://www.scopus.com/inward/record.url?scp=85050188557&partnerID=8YFLogxK
U2 - 10.1002/9781118951149.ch22
DO - 10.1002/9781118951149.ch22
M3 - Book chapter
AN - SCOPUS:85050188557
SN - 9781118951118
SP - 387
EP - 412
BT - Moonlighting Proteins
PB - Wiley-Blackwell
ER -
ID: 373882992