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Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. / Munk, Patrick; Brinch, Christian; Møller, Frederik Duus; Petersen, Thomas N.; Hendriksen, Rene S.; Seyfarth, Anne Mette; Kjeldgaard, Jette S.; Svendsen, Christina Aaby; van Bunnik, Bram; Berglund, Fanny; Bego, Artan; Power, Pablo; Rees, Catherine; Lambrinidis, Dionisia; Neilson, Elizabeth Heather Jakobsen; Gibb, Karen; Coventry, Kris; Collignon, Peter; Cassar, Susan; Allerberger, Franz; Begum, Anowara; Hossain, Zenat Zebin; Worrell, Carlon; Vandenberg, Olivier; Pieters, Ilse; Victorien, Dougnon Tamègnon; Gutierrez, Angela Daniela Salazar; Soria, Freddy; Grujić, Vesna Rudić; Mazalica, Nataša; Rahube, Teddie O.; Tagliati, Carlos Alberto; Rodrigues, Dalia; Oliveira, Guilherme; de Souza, Larissa Camila Ribeiro; Ivanov, Ivan; Juste, Bonkoungou Isidore; Oumar, Traoré; Sopheak, Thet; Vuthy, Yith; Ngandijo, Antoinette; Nzouankeu, Ariane; Olivier, Ziem A.Abah Jacques; Yost, Christopher K.; Hansen, Lisbeth Truelstrup; Jensen, Pernille Erland; Parimannan, Sivachandran; Hounmanou, Yaovi Mahuton Gildas; Thomsen, Jens; Aarestrup, Frank M.; Global Sewage Surveillance Consortium.
I:
Nature Communications, Bind 13, 7251, 2022.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Munk, P, Brinch, C, Møller, FD, Petersen, TN, Hendriksen, RS, Seyfarth, AM, Kjeldgaard, JS, Svendsen, CA, van Bunnik, B, Berglund, F, Bego, A, Power, P, Rees, C, Lambrinidis, D
, Neilson, EHJ, Gibb, K, Coventry, K, Collignon, P, Cassar, S, Allerberger, F, Begum, A, Hossain, ZZ, Worrell, C, Vandenberg, O, Pieters, I, Victorien, DT, Gutierrez, ADS, Soria, F, Grujić, VR, Mazalica, N, Rahube, TO, Tagliati, CA, Rodrigues, D, Oliveira, G, de Souza, LCR, Ivanov, I, Juste, BI, Oumar, T, Sopheak, T, Vuthy, Y, Ngandijo, A, Nzouankeu, A, Olivier, ZAAJ, Yost, CK, Hansen, LT, Jensen, PE, Parimannan, S
, Hounmanou, YMG, Thomsen, J, Aarestrup, FM & Global Sewage Surveillance Consortium 2022, '
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance',
Nature Communications, bind 13, 7251.
https://doi.org/10.1038/s41467-022-34312-7APA
Munk, P., Brinch, C., Møller, F. D., Petersen, T. N., Hendriksen, R. S., Seyfarth, A. M., Kjeldgaard, J. S., Svendsen, C. A., van Bunnik, B., Berglund, F., Bego, A., Power, P., Rees, C., Lambrinidis, D.
, Neilson, E. H. J., Gibb, K., Coventry, K., Collignon, P., Cassar, S., ... Global Sewage Surveillance Consortium (2022).
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance.
Nature Communications,
13, [7251].
https://doi.org/10.1038/s41467-022-34312-7Vancouver
Munk P, Brinch C, Møller FD, Petersen TN, Hendriksen RS, Seyfarth AM o.a.
Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance.
Nature Communications. 2022;13. 7251.
https://doi.org/10.1038/s41467-022-34312-7Author
Munk, Patrick ; Brinch, Christian ; Møller, Frederik Duus ; Petersen, Thomas N. ; Hendriksen, Rene S. ; Seyfarth, Anne Mette ; Kjeldgaard, Jette S. ; Svendsen, Christina Aaby ; van Bunnik, Bram ; Berglund, Fanny ; Bego, Artan ; Power, Pablo ; Rees, Catherine ; Lambrinidis, Dionisia ; Neilson, Elizabeth Heather Jakobsen ; Gibb, Karen ; Coventry, Kris ; Collignon, Peter ; Cassar, Susan ; Allerberger, Franz ; Begum, Anowara ; Hossain, Zenat Zebin ; Worrell, Carlon ; Vandenberg, Olivier ; Pieters, Ilse ; Victorien, Dougnon Tamègnon ; Gutierrez, Angela Daniela Salazar ; Soria, Freddy ; Grujić, Vesna Rudić ; Mazalica, Nataša ; Rahube, Teddie O. ; Tagliati, Carlos Alberto ; Rodrigues, Dalia ; Oliveira, Guilherme ; de Souza, Larissa Camila Ribeiro ; Ivanov, Ivan ; Juste, Bonkoungou Isidore ; Oumar, Traoré ; Sopheak, Thet ; Vuthy, Yith ; Ngandijo, Antoinette ; Nzouankeu, Ariane ; Olivier, Ziem A.Abah Jacques ; Yost, Christopher K. ; Hansen, Lisbeth Truelstrup ; Jensen, Pernille Erland ; Parimannan, Sivachandran ; Hounmanou, Yaovi Mahuton Gildas ; Thomsen, Jens ; Aarestrup, Frank M. ; Global Sewage Surveillance Consortium. / Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. I: Nature Communications. 2022 ; Bind 13.
Bibtex
@article{c8e81d5d3fa6408091c2771d00788678,
title = "Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance",
abstract = "Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.",
author = "Patrick Munk and Christian Brinch and M{\o}ller, {Frederik Duus} and Petersen, {Thomas N.} and Hendriksen, {Rene S.} and Seyfarth, {Anne Mette} and Kjeldgaard, {Jette S.} and Svendsen, {Christina Aaby} and {van Bunnik}, Bram and Fanny Berglund and Artan Bego and Pablo Power and Catherine Rees and Dionisia Lambrinidis and Neilson, {Elizabeth Heather Jakobsen} and Karen Gibb and Kris Coventry and Peter Collignon and Susan Cassar and Franz Allerberger and Anowara Begum and Hossain, {Zenat Zebin} and Carlon Worrell and Olivier Vandenberg and Ilse Pieters and Victorien, {Dougnon Tam{\`e}gnon} and Gutierrez, {Angela Daniela Salazar} and Freddy Soria and Gruji{\'c}, {Vesna Rudi{\'c}} and Nata{\v s}a Mazalica and Rahube, {Teddie O.} and Tagliati, {Carlos Alberto} and Dalia Rodrigues and Guilherme Oliveira and {de Souza}, {Larissa Camila Ribeiro} and Ivan Ivanov and Juste, {Bonkoungou Isidore} and Traor{\'e} Oumar and Thet Sopheak and Yith Vuthy and Antoinette Ngandijo and Ariane Nzouankeu and Olivier, {Ziem A.Abah Jacques} and Yost, {Christopher K.} and Hansen, {Lisbeth Truelstrup} and Jensen, {Pernille Erland} and Sivachandran Parimannan and Hounmanou, {Yaovi Mahuton Gildas} and Jens Thomsen and Aarestrup, {Frank M.} and {Global Sewage Surveillance Consortium}",
note = "Correction: 10.1038/s41467-023-35890-w Funding Information: We would like to thank everyone who has helped with sampling, shipping, and the logistics of transporting sewage to Denmark since the beginning of the pilot project including the Drainage Services Department, The Government of the Hong Kong Special Administrative Region. We also want to thank the system administrators of Computerome, for troubleshooting, guidance, and compute resources. A special thanks to the laboratory technicians at DTU who worked hard to receive and treat the incoming sewage and Elena Lavinia Diaconu (IZSLT). Lastly, we would like to acknowledge the Novo Nordisk Foundation (Grant: NNF16OC0021856: Global Surveillance of Antimicrobial Resistance) and the European Union{\textquoteright}s Horizon 2020 research and innovation programme (Grant: 874735) for funding the work. Funding Information: We would like to thank everyone who has helped with sampling, shipping, and the logistics of transporting sewage to Denmark since the beginning of the pilot project including the Drainage Services Department, The Government of the Hong Kong Special Administrative Region. We also want to thank the system administrators of Computerome, for troubleshooting, guidance, and compute resources. A special thanks to the laboratory technicians at DTU who worked hard to receive and treat the incoming sewage and Elena Lavinia Diaconu (IZSLT). Lastly, we would like to acknowledge the Novo Nordisk Foundation (Grant: NNF16OC0021856: Global Surveillance of Antimicrobial Resistance) and the European Union{\textquoteright}s Horizon 2020 research and innovation programme (Grant: 874735) for funding the work. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41467-022-34312-7",
language = "English",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
AU - Munk, Patrick
AU - Brinch, Christian
AU - Møller, Frederik Duus
AU - Petersen, Thomas N.
AU - Hendriksen, Rene S.
AU - Seyfarth, Anne Mette
AU - Kjeldgaard, Jette S.
AU - Svendsen, Christina Aaby
AU - van Bunnik, Bram
AU - Berglund, Fanny
AU - Bego, Artan
AU - Power, Pablo
AU - Rees, Catherine
AU - Lambrinidis, Dionisia
AU - Neilson, Elizabeth Heather Jakobsen
AU - Gibb, Karen
AU - Coventry, Kris
AU - Collignon, Peter
AU - Cassar, Susan
AU - Allerberger, Franz
AU - Begum, Anowara
AU - Hossain, Zenat Zebin
AU - Worrell, Carlon
AU - Vandenberg, Olivier
AU - Pieters, Ilse
AU - Victorien, Dougnon Tamègnon
AU - Gutierrez, Angela Daniela Salazar
AU - Soria, Freddy
AU - Grujić, Vesna Rudić
AU - Mazalica, Nataša
AU - Rahube, Teddie O.
AU - Tagliati, Carlos Alberto
AU - Rodrigues, Dalia
AU - Oliveira, Guilherme
AU - de Souza, Larissa Camila Ribeiro
AU - Ivanov, Ivan
AU - Juste, Bonkoungou Isidore
AU - Oumar, Traoré
AU - Sopheak, Thet
AU - Vuthy, Yith
AU - Ngandijo, Antoinette
AU - Nzouankeu, Ariane
AU - Olivier, Ziem A.Abah Jacques
AU - Yost, Christopher K.
AU - Hansen, Lisbeth Truelstrup
AU - Jensen, Pernille Erland
AU - Parimannan, Sivachandran
AU - Hounmanou, Yaovi Mahuton Gildas
AU - Thomsen, Jens
AU - Aarestrup, Frank M.
AU - Global Sewage Surveillance Consortium
N1 - Correction: 10.1038/s41467-023-35890-w
Funding Information:
We would like to thank everyone who has helped with sampling, shipping, and the logistics of transporting sewage to Denmark since the beginning of the pilot project including the Drainage Services Department, The Government of the Hong Kong Special Administrative Region. We also want to thank the system administrators of Computerome, for troubleshooting, guidance, and compute resources. A special thanks to the laboratory technicians at DTU who worked hard to receive and treat the incoming sewage and Elena Lavinia Diaconu (IZSLT). Lastly, we would like to acknowledge the Novo Nordisk Foundation (Grant: NNF16OC0021856: Global Surveillance of Antimicrobial Resistance) and the European Union’s Horizon 2020 research and innovation programme (Grant: 874735) for funding the work.
Funding Information:
We would like to thank everyone who has helped with sampling, shipping, and the logistics of transporting sewage to Denmark since the beginning of the pilot project including the Drainage Services Department, The Government of the Hong Kong Special Administrative Region. We also want to thank the system administrators of Computerome, for troubleshooting, guidance, and compute resources. A special thanks to the laboratory technicians at DTU who worked hard to receive and treat the incoming sewage and Elena Lavinia Diaconu (IZSLT). Lastly, we would like to acknowledge the Novo Nordisk Foundation (Grant: NNF16OC0021856: Global Surveillance of Antimicrobial Resistance) and the European Union’s Horizon 2020 research and innovation programme (Grant: 874735) for funding the work.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
AB - Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
U2 - 10.1038/s41467-022-34312-7
DO - 10.1038/s41467-022-34312-7
M3 - Journal article
C2 - 36456547
AN - SCOPUS:85143185703
VL - 13
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 7251
ER -
