HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma

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Standard

HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. / Hjalgrim, Henrik; Rostgaard, Klaus; Johnson, Paul C.D.; Shield, Lesley; Little, Ann Margaret; Ekstrom-Smedby, Karin; Adami, Hans Olov; Glimelius, Bengt; Hamilton-Dutoit, Stephen; Kane, Eleanor; Malcolm Taylor, G.; McConnachie, Alex; Ryder, Lars P.; Sundstrom, Christer; Andersen, Paal Skyt; Chang, Ellen T.; Alexander, Freda E.; Melbye, Mads; Jarrett, Ruth F.

I: Proceedings of the National Academy of Sciences of the United States of America, Bind 107, Nr. 14, 06.04.2010, s. 6400-6405.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hjalgrim, H, Rostgaard, K, Johnson, PCD, Shield, L, Little, AM, Ekstrom-Smedby, K, Adami, HO, Glimelius, B, Hamilton-Dutoit, S, Kane, E, Malcolm Taylor, G, McConnachie, A, Ryder, LP, Sundstrom, C, Andersen, PS, Chang, ET, Alexander, FE, Melbye, M & Jarrett, RF 2010, 'HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma', Proceedings of the National Academy of Sciences of the United States of America, bind 107, nr. 14, s. 6400-6405. https://doi.org/10.1073/pnas.0915054107

APA

Hjalgrim, H., Rostgaard, K., Johnson, P. C. D., Shield, L., Little, A. M., Ekstrom-Smedby, K., Adami, H. O., Glimelius, B., Hamilton-Dutoit, S., Kane, E., Malcolm Taylor, G., McConnachie, A., Ryder, L. P., Sundstrom, C., Andersen, P. S., Chang, E. T., Alexander, F. E., Melbye, M., & Jarrett, R. F. (2010). HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 107(14), 6400-6405. https://doi.org/10.1073/pnas.0915054107

Vancouver

Hjalgrim H, Rostgaard K, Johnson PCD, Shield L, Little AM, Ekstrom-Smedby K o.a. HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 2010 apr. 6;107(14):6400-6405. https://doi.org/10.1073/pnas.0915054107

Author

Hjalgrim, Henrik ; Rostgaard, Klaus ; Johnson, Paul C.D. ; Shield, Lesley ; Little, Ann Margaret ; Ekstrom-Smedby, Karin ; Adami, Hans Olov ; Glimelius, Bengt ; Hamilton-Dutoit, Stephen ; Kane, Eleanor ; Malcolm Taylor, G. ; McConnachie, Alex ; Ryder, Lars P. ; Sundstrom, Christer ; Andersen, Paal Skyt ; Chang, Ellen T. ; Alexander, Freda E. ; Melbye, Mads ; Jarrett, Ruth F. / HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma. I: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Bind 107, Nr. 14. s. 6400-6405.

Bibtex

@article{9afbc814febc425e8ca4a3fa87b23d8c,
title = "HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma",
abstract = "A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associatedwith risk of EBV-related HL. To study the host genetic component of EBV-related HL further, we investigated the lymphoma's association with HLA-A*01 and HLA-A*02 simultaneously in the setting of infectious mononucleosis (IM), a risk factor for EBV-related HL, in a case-series analysis including 278 EBV-related and 656 EBV-unrelated cases of HL. By logistic regression, HLA-A*01 alleles [odds ratio (OR) per allele, 2.15; 95% CI, 1.60-2.88] were associated with increased and HLA-A*02 alleles (OR per allele, 0.70; 95% CI, 0.51-0.97) with decreased risk of EBV-related HL. These allele-specific associations corresponded to nearly 10-fold variation in risk of EBV-related HL between HLA-A*01 and HLA-A*02 homozygotes. History of IM was also associated with risk of EBV-related HL (OR, 3.40; 95% CI, 1.74-6.66). The association between history of IM and EBV-related HL was not seen in the presence of HLA-A*02 because this allele appeared to neutralize the effect of IM on EBV-related HL risk. Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infectionin IM play critical roles in the pathogenesis of EBV-related HL.",
keywords = "Case series, Epidemiology",
author = "Henrik Hjalgrim and Klaus Rostgaard and Johnson, {Paul C.D.} and Lesley Shield and Little, {Ann Margaret} and Karin Ekstrom-Smedby and Adami, {Hans Olov} and Bengt Glimelius and Stephen Hamilton-Dutoit and Eleanor Kane and {Malcolm Taylor}, G. and Alex McConnachie and Ryder, {Lars P.} and Christer Sundstrom and Andersen, {Paal Skyt} and Chang, {Ellen T.} and Alexander, {Freda E.} and Mads Melbye and Jarrett, {Ruth F.}",
year = "2010",
month = apr,
day = "6",
doi = "10.1073/pnas.0915054107",
language = "English",
volume = "107",
pages = "6400--6405",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "14",

}

RIS

TY - JOUR

T1 - HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma

AU - Hjalgrim, Henrik

AU - Rostgaard, Klaus

AU - Johnson, Paul C.D.

AU - Shield, Lesley

AU - Little, Ann Margaret

AU - Ekstrom-Smedby, Karin

AU - Adami, Hans Olov

AU - Glimelius, Bengt

AU - Hamilton-Dutoit, Stephen

AU - Kane, Eleanor

AU - Malcolm Taylor, G.

AU - McConnachie, Alex

AU - Ryder, Lars P.

AU - Sundstrom, Christer

AU - Andersen, Paal Skyt

AU - Chang, Ellen T.

AU - Alexander, Freda E.

AU - Melbye, Mads

AU - Jarrett, Ruth F.

PY - 2010/4/6

Y1 - 2010/4/6

N2 - A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associatedwith risk of EBV-related HL. To study the host genetic component of EBV-related HL further, we investigated the lymphoma's association with HLA-A*01 and HLA-A*02 simultaneously in the setting of infectious mononucleosis (IM), a risk factor for EBV-related HL, in a case-series analysis including 278 EBV-related and 656 EBV-unrelated cases of HL. By logistic regression, HLA-A*01 alleles [odds ratio (OR) per allele, 2.15; 95% CI, 1.60-2.88] were associated with increased and HLA-A*02 alleles (OR per allele, 0.70; 95% CI, 0.51-0.97) with decreased risk of EBV-related HL. These allele-specific associations corresponded to nearly 10-fold variation in risk of EBV-related HL between HLA-A*01 and HLA-A*02 homozygotes. History of IM was also associated with risk of EBV-related HL (OR, 3.40; 95% CI, 1.74-6.66). The association between history of IM and EBV-related HL was not seen in the presence of HLA-A*02 because this allele appeared to neutralize the effect of IM on EBV-related HL risk. Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infectionin IM play critical roles in the pathogenesis of EBV-related HL.

AB - A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associatedwith risk of EBV-related HL. To study the host genetic component of EBV-related HL further, we investigated the lymphoma's association with HLA-A*01 and HLA-A*02 simultaneously in the setting of infectious mononucleosis (IM), a risk factor for EBV-related HL, in a case-series analysis including 278 EBV-related and 656 EBV-unrelated cases of HL. By logistic regression, HLA-A*01 alleles [odds ratio (OR) per allele, 2.15; 95% CI, 1.60-2.88] were associated with increased and HLA-A*02 alleles (OR per allele, 0.70; 95% CI, 0.51-0.97) with decreased risk of EBV-related HL. These allele-specific associations corresponded to nearly 10-fold variation in risk of EBV-related HL between HLA-A*01 and HLA-A*02 homozygotes. History of IM was also associated with risk of EBV-related HL (OR, 3.40; 95% CI, 1.74-6.66). The association between history of IM and EBV-related HL was not seen in the presence of HLA-A*02 because this allele appeared to neutralize the effect of IM on EBV-related HL risk. Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infectionin IM play critical roles in the pathogenesis of EBV-related HL.

KW - Case series

KW - Epidemiology

UR - http://www.scopus.com/inward/record.url?scp=77950902491&partnerID=8YFLogxK

U2 - 10.1073/pnas.0915054107

DO - 10.1073/pnas.0915054107

M3 - Journal article

C2 - 20308568

AN - SCOPUS:77950902491

VL - 107

SP - 6400

EP - 6405

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 14

ER -

ID: 258216447