Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea
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Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea. / Rydal, Martin Peter; Gambino, Michela; Jørgensen, Claus Bøttcher; Poulsen, Louise Ladefoged; Brøndsted, Lone; Nielsen, Jens Peter.
I: BMC Veterinary Research, Bind 18, 382, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea
AU - Rydal, Martin Peter
AU - Gambino, Michela
AU - Jørgensen, Claus Bøttcher
AU - Poulsen, Louise Ladefoged
AU - Brøndsted, Lone
AU - Nielsen, Jens Peter
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 108 CFU or 1010 CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.
AB - Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 108 CFU or 1010 CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.
KW - Diarrhea
KW - Enterotoxigenic Escherichia coli
KW - Experimental infection
KW - F4 fimbriae
KW - Genetic marker
KW - Inoculum dose
KW - Piglet
KW - Post-weaning
U2 - 10.1186/s12917-022-03474-3
DO - 10.1186/s12917-022-03474-3
M3 - Journal article
C2 - 36320033
AN - SCOPUS:85140998201
VL - 18
JO - B M C Veterinary Research
JF - B M C Veterinary Research
SN - 1746-6148
M1 - 382
ER -
ID: 330935004