Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study
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Prevalence of infective endocarditis in patients with positive blood cultures : a Danish nationwide study. / Østergaard, Lauge; Bruun, Niels Eske; Voldstedlund, Marianne; Arpi, Magnus; Andersen, Christian Østergaard; Schønheyder, Henrik C.; Lemming, Lars; Rosenvinge, Flemming; Valeur, Nana; Søgaard, Peter; Andersen, Paal Skytt; Skov, Robert; Chen, Ming; Iversen, Kasper; Gill, Sabine; Lauridsen, Trine Kiilerich; Dahl, Anders; Oestergaard, Louise Bruun; Povlsen, Jonas Agerlund; Moser, Claus; Bundgaard, Henning; Køber, Lars; Fosbøl, Emil Loldrup.
I: European Heart Journal, Bind 40, Nr. 39, 2019, s. 3237-3244.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prevalence of infective endocarditis in patients with positive blood cultures
T2 - a Danish nationwide study
AU - Østergaard, Lauge
AU - Bruun, Niels Eske
AU - Voldstedlund, Marianne
AU - Arpi, Magnus
AU - Andersen, Christian Østergaard
AU - Schønheyder, Henrik C.
AU - Lemming, Lars
AU - Rosenvinge, Flemming
AU - Valeur, Nana
AU - Søgaard, Peter
AU - Andersen, Paal Skytt
AU - Skov, Robert
AU - Chen, Ming
AU - Iversen, Kasper
AU - Gill, Sabine
AU - Lauridsen, Trine Kiilerich
AU - Dahl, Anders
AU - Oestergaard, Louise Bruun
AU - Povlsen, Jonas Agerlund
AU - Moser, Claus
AU - Bundgaard, Henning
AU - Køber, Lars
AU - Fosbøl, Emil Loldrup
PY - 2019
Y1 - 2019
N2 - AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE. METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age. CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.
AB - AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE. METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age. CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI.
KW - Blood stream infection
KW - Infective endocarditis
KW - Population study
U2 - 10.1093/eurheartj/ehz327
DO - 10.1093/eurheartj/ehz327
M3 - Journal article
C2 - 31145782
AN - SCOPUS:85070070001
VL - 40
SP - 3237
EP - 3244
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 39
ER -
ID: 229064775