Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Fatality Rate among Elderly Danes: A Cross-sectional Study on Retired Blood Donors
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Fatality Rate among Elderly Danes : A Cross-sectional Study on Retired Blood Donors. / Pedersen, Ole Birger; Nissen, Janna; Dinh, Khoa Manh; Schwinn, Michael; Kaspersen, Kathrine Agergård; Boldsen, Jens Kjærgaard; Didriksen, Maria; Dowsett, Joseph; Sørensen, Erik; Thørner, Lise Wegner; Larsen, Margit Anita Hørup; Grum-Schwensen, Birgitte; Sækmose, Susanne; Paulsen, Isabella Worlewenut; Frisk, Nanna Lond Skov; Brodersen, Thorsten; Vestergaard, Lasse Skafte; Rostgaard, Klaus; Mølbak, Kåre; Skov, Robert Leo; Erikstrup, Christian; Ullum, Henrik; Hjalgrim, Henrik.
I: Clinical Infectious Diseases, Bind 73, Nr. 9, 2021, s. E2962-E2969.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Fatality Rate among Elderly Danes
T2 - A Cross-sectional Study on Retired Blood Donors
AU - Pedersen, Ole Birger
AU - Nissen, Janna
AU - Dinh, Khoa Manh
AU - Schwinn, Michael
AU - Kaspersen, Kathrine Agergård
AU - Boldsen, Jens Kjærgaard
AU - Didriksen, Maria
AU - Dowsett, Joseph
AU - Sørensen, Erik
AU - Thørner, Lise Wegner
AU - Larsen, Margit Anita Hørup
AU - Grum-Schwensen, Birgitte
AU - Sækmose, Susanne
AU - Paulsen, Isabella Worlewenut
AU - Frisk, Nanna Lond Skov
AU - Brodersen, Thorsten
AU - Vestergaard, Lasse Skafte
AU - Rostgaard, Klaus
AU - Mølbak, Kåre
AU - Skov, Robert Leo
AU - Erikstrup, Christian
AU - Ullum, Henrik
AU - Hjalgrim, Henrik
N1 - Publisher Copyright: © 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2021
Y1 - 2021
N2 - Background: Although the vast majority of individuals succumbing to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are elderly, infection fatality rate (IFR) estimates for the age group ≥70 years are still scarce. To this end, we assessed SARS-CoV-2 seroprevalence among retired blood donors and combined it with national coronavirus disease 2019 (COVID-19) survey data to provide reliable population-based IFR estimates for this age group. Methods: We identified 60â-926 retired blood donors aged ≥70 years in the rosters of 3 regionwide Danish blood banks and invited them to fill in a questionnaire on COVID-19-related symptoms and behaviors. Among 24â-861 (40.8%) responders, we invited a random sample of 3200 individuals for blood testing. Overall, 1201 (37.5%) individuals were tested for SARS-CoV-2 antibodies (Wantai) and compared with 1110 active blood donors aged 17-69 years. Seroprevalence 95% confidence intervals (CIs) were adjusted for assay sensitivity and specificity. Results: Among retired (aged ≥70 years) and active (aged 17-69 years) blood donors, adjusted seroprevalences were 1.4% (95% CI,. 3-2.5%) and 2.5% (95% CI, 1.3-3.8%), respectively. Using available population data on COVID-19-related fatalities, IFRs for patients aged ≥70 years and for 17-69 years were estimated at 5.4% (95% CI, 2.7-6.4%) and. 083% (95% CI,. 054-.18%), respectively. Only 52.4% of SARS-CoV-2-seropositive retired blood donors reported having been sick since the start of the pandemic. Conclusions: COVID-19 IFR in the age group >69 years is estimated to be 65 times the IFR for people aged 18-69 years.
AB - Background: Although the vast majority of individuals succumbing to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are elderly, infection fatality rate (IFR) estimates for the age group ≥70 years are still scarce. To this end, we assessed SARS-CoV-2 seroprevalence among retired blood donors and combined it with national coronavirus disease 2019 (COVID-19) survey data to provide reliable population-based IFR estimates for this age group. Methods: We identified 60â-926 retired blood donors aged ≥70 years in the rosters of 3 regionwide Danish blood banks and invited them to fill in a questionnaire on COVID-19-related symptoms and behaviors. Among 24â-861 (40.8%) responders, we invited a random sample of 3200 individuals for blood testing. Overall, 1201 (37.5%) individuals were tested for SARS-CoV-2 antibodies (Wantai) and compared with 1110 active blood donors aged 17-69 years. Seroprevalence 95% confidence intervals (CIs) were adjusted for assay sensitivity and specificity. Results: Among retired (aged ≥70 years) and active (aged 17-69 years) blood donors, adjusted seroprevalences were 1.4% (95% CI,. 3-2.5%) and 2.5% (95% CI, 1.3-3.8%), respectively. Using available population data on COVID-19-related fatalities, IFRs for patients aged ≥70 years and for 17-69 years were estimated at 5.4% (95% CI, 2.7-6.4%) and. 083% (95% CI,. 054-.18%), respectively. Only 52.4% of SARS-CoV-2-seropositive retired blood donors reported having been sick since the start of the pandemic. Conclusions: COVID-19 IFR in the age group >69 years is estimated to be 65 times the IFR for people aged 18-69 years.
KW - COVID-19
KW - epidemiology
KW - infection fatality rate
KW - SARS-Cov-2 antibody test
KW - SARS-CoV-2 seroprevalence
U2 - 10.1093/cid/ciaa1627
DO - 10.1093/cid/ciaa1627
M3 - Journal article
C2 - 33103182
AN - SCOPUS:85120613959
VL - 73
SP - E2962-E2969
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 9
ER -
ID: 288188605