TY - JOUR

T1 - Sources and fate of antimicrobials in integrated fish-pig and non-integrated tilapia farms

AU - Li, Kang

AU - Liu, Liping

AU - Zhan, Jia

AU - Scippo, Marie Louise

AU - Hvidtfeldt, Kristian

AU - Liu, Yuan

AU - Dalsgaard, Anders

PY - 2017

Y1 - 2017

N2 - Antimicrobial contamination in aquaculture products constitutes a food safety hazard, but little is known about the introduction and accumulation of antimicrobials in integrated fish-pig aquaculture. This study, conducted in 2013, aimed to determine the residues of 11 types of antimicrobials by UPLC-MS/MS analysis in fish feed (n = 37), pig feed (n = 9), pig manure (n = 9), pond sediment (n = 20), fish skin (n = 20) and muscle tissue (n = 20) sampled from integrated tilapia-pig farms, non-integrated tilapia farms and fish feed supply shops. There was a higher occurrence of antimicrobial residues in fish skin from both integrated and non-integrated farms, and in pig manure. Enrofloxacin (3.9–129.3 μg/kg) and sulfadiazine (0.7–7.8 μg/kg) were commonly detected in fish skin and muscle, pig manure and pond sediment from integrated farms, with different types of antimicrobials found in pig manure and tilapia samples. In non-integrated farms, sulfadiazine (2.5–89.9 μg/kg) was the predominant antimicrobial detected in fish skin and muscle, fish feed and pond sediment. In general, antimicrobials seemed not to be commonly transmitted from pig to fish in tilapia-pig integrated farms, and fish feed, pig feed and pond sediment did not seem as important sources of the antimicrobials found in fish from both systems. The frequent findings of antimicrobial residues in fish skin compared with fish muscle was probably due to different pharmacokinetics in different tissue types, which have practical food safety implications since antimicrobial residues monitoring is usually performed analyzing mixed skin and fish muscle samples.

AB - Antimicrobial contamination in aquaculture products constitutes a food safety hazard, but little is known about the introduction and accumulation of antimicrobials in integrated fish-pig aquaculture. This study, conducted in 2013, aimed to determine the residues of 11 types of antimicrobials by UPLC-MS/MS analysis in fish feed (n = 37), pig feed (n = 9), pig manure (n = 9), pond sediment (n = 20), fish skin (n = 20) and muscle tissue (n = 20) sampled from integrated tilapia-pig farms, non-integrated tilapia farms and fish feed supply shops. There was a higher occurrence of antimicrobial residues in fish skin from both integrated and non-integrated farms, and in pig manure. Enrofloxacin (3.9–129.3 μg/kg) and sulfadiazine (0.7–7.8 μg/kg) were commonly detected in fish skin and muscle, pig manure and pond sediment from integrated farms, with different types of antimicrobials found in pig manure and tilapia samples. In non-integrated farms, sulfadiazine (2.5–89.9 μg/kg) was the predominant antimicrobial detected in fish skin and muscle, fish feed and pond sediment. In general, antimicrobials seemed not to be commonly transmitted from pig to fish in tilapia-pig integrated farms, and fish feed, pig feed and pond sediment did not seem as important sources of the antimicrobials found in fish from both systems. The frequent findings of antimicrobial residues in fish skin compared with fish muscle was probably due to different pharmacokinetics in different tissue types, which have practical food safety implications since antimicrobial residues monitoring is usually performed analyzing mixed skin and fish muscle samples.

KW - Antimicrobial residues

KW - Feed

KW - Integrated production system

KW - Pig manure

KW - Sediment

KW - Tilapia

U2 - 10.1016/j.scitotenv.2017.01.124

DO - 10.1016/j.scitotenv.2017.01.124

M3 - Journal article

C2 - 28391144

AN - SCOPUS:85017167246

VL - 595

SP - 393

EP - 399

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -