Staphylococcus aureus and the ecology of the nasal microbiome

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Staphylococcus aureus and the ecology of the nasal microbiome. / Liu, Cindy M; Price, Lance B; Hungate, Bruce A; Abraham, Alison G; Larsen, Lisbeth A.; Christensen, Kaare; Stegger, Marc; Skov, Robert; Andersen, Paal Skytt.

I: Science Advances, Bind 1, Nr. 5, e1400216, 06.2015.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Liu, CM, Price, LB, Hungate, BA, Abraham, AG, Larsen, LA, Christensen, K, Stegger, M, Skov, R & Andersen, PS 2015, 'Staphylococcus aureus and the ecology of the nasal microbiome', Science Advances, bind 1, nr. 5, e1400216. https://doi.org/10.1126/sciadv.1400216

APA

Liu, C. M., Price, L. B., Hungate, B. A., Abraham, A. G., Larsen, L. A., Christensen, K., Stegger, M., Skov, R., & Andersen, P. S. (2015). Staphylococcus aureus and the ecology of the nasal microbiome. Science Advances, 1(5), [e1400216]. https://doi.org/10.1126/sciadv.1400216

Vancouver

Liu CM, Price LB, Hungate BA, Abraham AG, Larsen LA, Christensen K o.a. Staphylococcus aureus and the ecology of the nasal microbiome. Science Advances. 2015 jun.;1(5). e1400216. https://doi.org/10.1126/sciadv.1400216

Author

Liu, Cindy M ; Price, Lance B ; Hungate, Bruce A ; Abraham, Alison G ; Larsen, Lisbeth A. ; Christensen, Kaare ; Stegger, Marc ; Skov, Robert ; Andersen, Paal Skytt. / Staphylococcus aureus and the ecology of the nasal microbiome. I: Science Advances. 2015 ; Bind 1, Nr. 5.

Bibtex

@article{5505a262bc25445598eefc52305d6874,
title = "Staphylococcus aureus and the ecology of the nasal microbiome",
abstract = "The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.",
author = "Liu, {Cindy M} and Price, {Lance B} and Hungate, {Bruce A} and Abraham, {Alison G} and Larsen, {Lisbeth A.} and Kaare Christensen and Marc Stegger and Robert Skov and Andersen, {Paal Skytt}",
year = "2015",
month = jun,
doi = "10.1126/sciadv.1400216",
language = "English",
volume = "1",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Staphylococcus aureus and the ecology of the nasal microbiome

AU - Liu, Cindy M

AU - Price, Lance B

AU - Hungate, Bruce A

AU - Abraham, Alison G

AU - Larsen, Lisbeth A.

AU - Christensen, Kaare

AU - Stegger, Marc

AU - Skov, Robert

AU - Andersen, Paal Skytt

PY - 2015/6

Y1 - 2015/6

N2 - The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

AB - The human microbiome can play a key role in host susceptibility to pathogens, including in the nasal cavity, a site favored by Staphylococcus aureus. However, what determines our resident nasal microbiota-the host or the environment-and can interactions among nasal bacteria determine S. aureus colonization? Our study of 46 monozygotic and 43 dizygotic twin pairs revealed that nasal microbiota is an environmentally derived trait, but the host's sex and genetics significantly influence nasal bacterial density. Although specific taxa, including lactic acid bacteria, can determine S. aureus colonization, their negative interactions depend on thresholds of absolute abundance. These findings demonstrate that nasal microbiota is not fixed by host genetics and opens the possibility that nasal microbiota may be manipulated to prevent or eliminate S. aureus colonization.

U2 - 10.1126/sciadv.1400216

DO - 10.1126/sciadv.1400216

M3 - Journal article

C2 - 26601194

VL - 1

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 5

M1 - e1400216

ER -

ID: 161554304