Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Standard

Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi. / Gless, Bengt Herbert; Peng, Pai; Pedersen, Katja D.; Gotfredsen, Charlotte H.; Ingmer, Hanne; Olsen, Christian Adam.

I: Organic Letters, Bind 19, Nr. 19, 2017, s. 5276–5279.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Gless, BH, Peng, P, Pedersen, KD, Gotfredsen, CH, Ingmer, H & Olsen, CA 2017, 'Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi', Organic Letters, bind 19, nr. 19, s. 5276–5279. https://doi.org/10.1021/acs.orglett.7b02550

APA

Gless, B. H., Peng, P., Pedersen, K. D., Gotfredsen, C. H., Ingmer, H., & Olsen, C. A. (2017). Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi. Organic Letters, 19(19), 5276–5279. https://doi.org/10.1021/acs.orglett.7b02550

Vancouver

Gless BH, Peng P, Pedersen KD, Gotfredsen CH, Ingmer H, Olsen CA. Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi. Organic Letters. 2017;19(19):5276–5279. https://doi.org/10.1021/acs.orglett.7b02550

Author

Gless, Bengt Herbert ; Peng, Pai ; Pedersen, Katja D. ; Gotfredsen, Charlotte H. ; Ingmer, Hanne ; Olsen, Christian Adam. / Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi. I: Organic Letters. 2017 ; Bind 19, Nr. 19. s. 5276–5279.

Bibtex

@article{025344db23ca4f2ba7c0ab3aef275891,
title = "Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi",
abstract = "Herein, an effective protocol for solid-phase synthesis of peptide thiolactones by concomitant ring closure and cleavage from the solid support is reported. The strategy was applied for mapping the importance of the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this natural compound. This furnished some of the most potent inhibitors of accessory gene regulator (agr)-I in the human pathogen S. aureus reported to date.",
author = "Gless, {Bengt Herbert} and Pai Peng and Pedersen, {Katja D.} and Gotfredsen, {Charlotte H.} and Hanne Ingmer and Olsen, {Christian Adam}",
year = "2017",
doi = "10.1021/acs.orglett.7b02550",
language = "English",
volume = "19",
pages = "5276–5279",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",

}

RIS

TY - JOUR

T1 - Structure-activity relationship study based on Autoinducing Peptide (AIP) from dog pathogen S. schleiferi

AU - Gless, Bengt Herbert

AU - Peng, Pai

AU - Pedersen, Katja D.

AU - Gotfredsen, Charlotte H.

AU - Ingmer, Hanne

AU - Olsen, Christian Adam

PY - 2017

Y1 - 2017

N2 - Herein, an effective protocol for solid-phase synthesis of peptide thiolactones by concomitant ring closure and cleavage from the solid support is reported. The strategy was applied for mapping the importance of the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this natural compound. This furnished some of the most potent inhibitors of accessory gene regulator (agr)-I in the human pathogen S. aureus reported to date.

AB - Herein, an effective protocol for solid-phase synthesis of peptide thiolactones by concomitant ring closure and cleavage from the solid support is reported. The strategy was applied for mapping the importance of the structural features in S. schleiferi AIP (5) by performing an alanine scan and truncation of this natural compound. This furnished some of the most potent inhibitors of accessory gene regulator (agr)-I in the human pathogen S. aureus reported to date.

U2 - 10.1021/acs.orglett.7b02550

DO - 10.1021/acs.orglett.7b02550

M3 - Letter

C2 - 28952740

VL - 19

SP - 5276

EP - 5279

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 19

ER -

ID: 184203354