Delayed growth, motor function and learning in preterm pigs during early postnatal life
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Delayed growth, motor function and learning in preterm pigs during early postnatal life. / Andersen, Anders D.; Sangild, Per T.; Munch, Sara L.; van der Beek, Eline M.; Renes, Ingrid B.; Ginneken, Chris Van; Greisen, Gorm O.; Thymann, Thomas.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 310, Nr. 6, 15.03.2016, s. R481-R492.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Delayed growth, motor function and learning in preterm pigs during early postnatal life
AU - Andersen, Anders D.
AU - Sangild, Per T.
AU - Munch, Sara L.
AU - van der Beek, Eline M.
AU - Renes, Ingrid B.
AU - Ginneken, Chris Van
AU - Greisen, Gorm O.
AU - Thymann, Thomas
N1 - Copyright © 2016 the American Physiological Society.
PY - 2016/3/15
Y1 - 2016/3/15
N2 - Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age, but some may persist into childhood. We hypothesized that preterm birth would induce impaired organ growth and function during the first postnatal week in pigs, while motor abilities and behavioral characteristics would show more persistent developmental delay. Cesarean-delivered preterm (n = 112, 90% gestation) or term (n = 56, 100% gestation) piglets were reared under identical conditions and euthanized for blood and organ collection on postnatal days 0, 5, or 26. Body weight gain remained lower in preterm vs. term pigs up to day 26 (25.5 ± 1.5 vs. 31.0 ± 0.5 g·kg(-1)·day(-1), P < 0.01) when relative weights were higher for brain and kidneys and reduced for liver and spleen. Neonatal preterm pigs had reduced values for blood pH, Po2, glucose, lactate, hematocrit, and cortisol, but at day 26, most values were normalized, although plasma serotonin and IGF 1 levels remained reduced. Preterm pigs showed delayed neonatal arousal and impaired physical activity, coordination, exploration, and learning, relative to term pigs (all P < 0.05). Supplementation of parenteral nutrition during the first 5 days with an enteral milk diet did not affect later outcomes. In preterm pigs, many physiological characteristics of immaturity disappeared by 4 wk, while some neurodevelopmental deficits remained. The preterm pig is a relevant animal model to study early dietary and pharmacological interventions that support postnatal maturation and neurodevelopment in preterm infants.
AB - Preterm birth interrupts normal fetal growth with consequences for postnatal growth and organ development. In preterm infants, many physiological deficits adapt and disappear with advancing postnatal age, but some may persist into childhood. We hypothesized that preterm birth would induce impaired organ growth and function during the first postnatal week in pigs, while motor abilities and behavioral characteristics would show more persistent developmental delay. Cesarean-delivered preterm (n = 112, 90% gestation) or term (n = 56, 100% gestation) piglets were reared under identical conditions and euthanized for blood and organ collection on postnatal days 0, 5, or 26. Body weight gain remained lower in preterm vs. term pigs up to day 26 (25.5 ± 1.5 vs. 31.0 ± 0.5 g·kg(-1)·day(-1), P < 0.01) when relative weights were higher for brain and kidneys and reduced for liver and spleen. Neonatal preterm pigs had reduced values for blood pH, Po2, glucose, lactate, hematocrit, and cortisol, but at day 26, most values were normalized, although plasma serotonin and IGF 1 levels remained reduced. Preterm pigs showed delayed neonatal arousal and impaired physical activity, coordination, exploration, and learning, relative to term pigs (all P < 0.05). Supplementation of parenteral nutrition during the first 5 days with an enteral milk diet did not affect later outcomes. In preterm pigs, many physiological characteristics of immaturity disappeared by 4 wk, while some neurodevelopmental deficits remained. The preterm pig is a relevant animal model to study early dietary and pharmacological interventions that support postnatal maturation and neurodevelopment in preterm infants.
KW - Animals
KW - Animals, Newborn
KW - Arousal
KW - Behavior, Animal
KW - Exploratory Behavior
KW - Female
KW - Gestational Age
KW - Growth Disorders
KW - Learning Disorders
KW - Male
KW - Motor Skills Disorders
KW - Movement Disorders
KW - Organ Size
KW - Parenteral Nutrition
KW - Pregnancy
KW - Sus scrofa
KW - Weight Gain
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1152/ajpregu.00349.2015
DO - 10.1152/ajpregu.00349.2015
M3 - Journal article
C2 - 26764054
VL - 310
SP - R481-R492
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 6
ER -
ID: 178840836