Trial-related blood sampling and red blood cell transfusions in preterm infants
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Trial-related blood sampling and red blood cell transfusions in preterm infants. / Lewis, Anna Elisabet; Kappel, Susanne S.; Hussain, Samya; Sangild, Per T.; Zachariassen, Gitte; Aunsholt, Lise.
I: Acta Paediatrica, Bind 112, Nr. 12, 2023, s. 2486-2492.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Trial-related blood sampling and red blood cell transfusions in preterm infants
AU - Lewis, Anna Elisabet
AU - Kappel, Susanne S.
AU - Hussain, Samya
AU - Sangild, Per T.
AU - Zachariassen, Gitte
AU - Aunsholt, Lise
N1 - Publisher Copyright: © 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
PY - 2023
Y1 - 2023
N2 - Aim: To determine if trial-related blood sampling increases the risk of later red blood cell (RBC) transfusion in very preterm infants, we compared the volume of clinical- and trial-related blood samples, in a specific trial and correlated to subsequent RBC transfusion. Methods: For 193 very preterm infants, participating in the FortiColos trial (NCT03537365), trial-related blood volume drawn was in accordance with ethical considerations established by the European Commission. Medical records were reviewed to assess the number and accumulated volume (mL/kg) of blood samples (both clinical- and trial-related). Data were compared with the need of RBC transfusions during the first 28 days of life. Results: Mean (SD) gestational age and birth weight was 28 ± 1 weeks and 1168 ± 301 g. In total, 11% of total blood volume was drawn for sampling (8.1 ± 5.1 mL/kg) and trial-related sampling accounted for 1.6 ± 0.6 mL/kg. Trial-related blood sampling had no impact on RBC transfusion (p = 0.9). Conclusion: Clinical blood sampling in very preterm infants is associated with blood loss and subsequent need for RBC transfusions. In a specific trial requiring blood samples, we found no additional burden of trial-related blood sampling. The study suggests that trial-related sampling is safe if European criteria are followed.
AB - Aim: To determine if trial-related blood sampling increases the risk of later red blood cell (RBC) transfusion in very preterm infants, we compared the volume of clinical- and trial-related blood samples, in a specific trial and correlated to subsequent RBC transfusion. Methods: For 193 very preterm infants, participating in the FortiColos trial (NCT03537365), trial-related blood volume drawn was in accordance with ethical considerations established by the European Commission. Medical records were reviewed to assess the number and accumulated volume (mL/kg) of blood samples (both clinical- and trial-related). Data were compared with the need of RBC transfusions during the first 28 days of life. Results: Mean (SD) gestational age and birth weight was 28 ± 1 weeks and 1168 ± 301 g. In total, 11% of total blood volume was drawn for sampling (8.1 ± 5.1 mL/kg) and trial-related sampling accounted for 1.6 ± 0.6 mL/kg. Trial-related blood sampling had no impact on RBC transfusion (p = 0.9). Conclusion: Clinical blood sampling in very preterm infants is associated with blood loss and subsequent need for RBC transfusions. In a specific trial requiring blood samples, we found no additional burden of trial-related blood sampling. The study suggests that trial-related sampling is safe if European criteria are followed.
KW - anaemia of prematurity
KW - blood sampling
KW - prematurity
KW - red blood cell transfusion
U2 - 10.1111/apa.16948
DO - 10.1111/apa.16948
M3 - Journal article
C2 - 37565393
AN - SCOPUS:85168348484
VL - 112
SP - 2486
EP - 2492
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 12
ER -
ID: 365823038