TY - JOUR

T1 - Vaccination timeliness of preterm infants hospitalised in a neonatal intensive care unit in Denmark

AU - Baggesgaard, Christine Manich Bech

AU - Poulsen, Anja

AU - Dungu, Kia Hee Schultz

AU - Jensen, Lotte

AU - Rahimi, Hanna

AU - Aunsholt, Lise

AU - Lund, Stine

N1 - Publisher Copyright: © 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

PY - 2023

Y1 - 2023

N2 - Aim: In Denmark, preterm infants are recommended to receive childhood vaccinations without correction for gestational age. This study aimed to describe the timeliness of the Danish Childhood Vaccination Program in preterm infants during the first 13 months of life and to evaluate possible determinants of delay. Methods: This retrospective cohort study included preterm infants admitted to a level III neonatal intensive care unit between October 2019 and October 2020. Clinical data were retrieved from medical records and the Danish Vaccination Register. Timely vaccination was defined corresponding to chronological age of 3-, 5- and 12 months, within a time interval of 30 days before to 29 days after the expected date. Results: Analyses included 365 infants. Timely vaccination occurred in 91%, 83% and 67% of preterm infants for the first, second and third vaccination, respectively, and timeliness was highest if born before gestational age 28 weeks. Gestational age 28–31 + 6 weeks and delayed former vaccinations negatively influenced the timeliness of the following vaccinations. Conclusion: Most preterm infants received the first vaccination timely; however, timeliness decreased with each subsequent vaccination. Efforts to improve timeliness should focus on counselling healthcare personnel and parents to follow the recommendations for the first and the following vaccinations.

AB - Aim: In Denmark, preterm infants are recommended to receive childhood vaccinations without correction for gestational age. This study aimed to describe the timeliness of the Danish Childhood Vaccination Program in preterm infants during the first 13 months of life and to evaluate possible determinants of delay. Methods: This retrospective cohort study included preterm infants admitted to a level III neonatal intensive care unit between October 2019 and October 2020. Clinical data were retrieved from medical records and the Danish Vaccination Register. Timely vaccination was defined corresponding to chronological age of 3-, 5- and 12 months, within a time interval of 30 days before to 29 days after the expected date. Results: Analyses included 365 infants. Timely vaccination occurred in 91%, 83% and 67% of preterm infants for the first, second and third vaccination, respectively, and timeliness was highest if born before gestational age 28 weeks. Gestational age 28–31 + 6 weeks and delayed former vaccinations negatively influenced the timeliness of the following vaccinations. Conclusion: Most preterm infants received the first vaccination timely; however, timeliness decreased with each subsequent vaccination. Efforts to improve timeliness should focus on counselling healthcare personnel and parents to follow the recommendations for the first and the following vaccinations.

KW - premature infant

KW - vaccination

KW - vaccination age

U2 - 10.1111/apa.16724

DO - 10.1111/apa.16724

M3 - Journal article

C2 - 36840369

AN - SCOPUS:85150273523

VL - 112

SP - 1190

EP - 1199

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 6

ER -