Glycoalkaloids (GA) are anti-nutritional factors in standard potato protein concentrate (PPC) fed to piglets. Increasing levels of standard PPC was expected to affect growth performance and fecal score negatively. Seven-hundred-and-twenty pigs (7–30 kg) were fed one of the following four diets within three feeding phases (days 0–13, 13–24, and 24–45): control (CTRL), PPC standard inclusion (PPC-S; 4%, 2%, and 0%), high PPC inclusion (PPC-H; 8%, 3.5%, and 2%), and extremely high PPC inclusion (PPC-EH; 12%, 5%, and 3.5%). During days 0–13, CTRL displayed no difference in growth performance compared with the three experimental groups (PPC-S, PPC-H, and PPC-EH). During days 13–24, PPC-H achieved greater (p < 0.001) average daily feed intake (ADFI) compared to CTRL. During days 24–45, no differences between groups were observed. For the overall experimental period (0–45 days), PPC-H displayed greater average daily gain (ADG) (p = 0.010) and ADFI (p = 0.024) compared to CTRL. The feed conversion ratio (FCR) remained unaffected between the groups for all experimental periods. Increasing levels of PPC and hence GA did not affect the probability of diarrhea. In conclusion, increased standard PPC and hence increased levels of GA in isonitrogenous diets did not negatively affect growth performance nor fecal score in piglets (7–30 kg).